Stock

FESA Number

1867

Strain Name

STOCK Bmp7<tm2Rob>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant stock

Attribution

Institution name Depositor / Originator Name
University of Oxford Originator Retained
University of Oxford Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Bmp7<tm2Rob> MGI:2136986 Bmp7 MGI:103302 2

Phenotypic Description

Homozygous embryonic lethal.

Publications

Displaying 1 - 10 of 21 Stock Publications
Pubmed ID Authors Title Journal
19855020 Bastida MF A BMP-Shh negative-feedback loop restricts Shh expression during limb development. Development (2 009) 136:3779-89
23991197 Tomita M Bmp7 maintains undifferentiated kidney progenitor population and determines nephron numbers at birth. PLoS One (2 013) 8:e73554
19474151 Beites CL Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue. Development (2 009) 136:2187-97
18719589 Tseng YH New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature (2 008) 454:1000-4
19793891 Blank U BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism. Development (2 009) 136:3557-66
19159697 Wu X Bmp7 expression and null phenotype in the urogenital system suggest a role in re-organization of the urethral epithelium. Gene Expr Patterns (2 009) 9:224-30
18082966 Chou J Bone morphogenetic protein-7 reduces toxicity induced by high doses of methamphetamine in rodents. Neuroscience (2 008) 151:92-103
22253716 Xu K Bmp7 functions via a polarity mechanism to promote cloacal septation. PLoS One (2 012) 7:e29372
15280212 Dean C Bmp7 regulates branching morphogenesis of the lacrimal gland by promoting mesenchymal proliferation and condensation. Development (2 004) 131:4155-65
19127565 Zouvelou V Deletion of BMP7 affects the development of bones, teeth, and other ectodermal appendages of the orofacial complex. J Exp Zool B Mol Dev Evol (2 009) 312B:361-74

Pages

EMMA ID

EM:02513

Genetic Status

GMO

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