Title Phenotype Contact
129(B6)-Apoe<tm1Bres> Plat<tm1Mlg>/CljH[cc] None. Contact
129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc] Rectal prolapse. Shortened life span in homozygotes. Contact
129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc] Shortened life span. Contact
129(B6)-Thy1<tm1Rjmo>/H Nervous system: reduced long term potentiation (J:31610). Strong inhibition of LTP in the dentate gyrus but not in CA1, however spatial learning as assessed in the watermaze is unimpaired. Respiratory system: pulmonary fibrosis (J:99951). Marked increase in severity of lung fibrosis and more extensive collagen deposition in response to intratracheal bleomycin, compared to controls. Contact
129(Cg)-Tecta<tm5.1Gpr>/GprH In Tecta<tm5.1Gpr>/<tm5.1Gpr> homozygotes the tectorial membrane is completely detached from the spiral limbus and is associated instead with the Reissner membrane. Tecta is virtually undetectable by immunofluorescence in the detached tectorial membrane, with the exception of some weak labelling at the extreme apical end. In heterozygous mice inner ear phenotype shows malformation of the tectorial membrane, ABR thresholds elevated by ~35 dB and an enhanced susceptibility to audiogenic seizure at low sound pressure levels. See PubMed 24363064 Legan et al Human Mol Genet 2013: Three deaf mice. Contact
129-Ctsg<tm1.1Roes>/H Mice deficient in Ctsg are susceptible to fungal infections, despite normal neutrophil development and recruitment. Contact
129-Elane<tm1(cre)Roes>/H Homozygotes have impaired neutrophil recruitment and impaired innate immunity. Contact
129-Elane<tm1(cre)Roes>Ctsg<tm1.1Roes>/H Impaired innate immunity. Contact
129-Epc1<tm1e(EUCOMM)Wtsi>/WtsiH To see phenotype data (when available) visit www.mousephenotype.org IMPC report a range of phenotypes for the tm1a allele, however these data should probably be assigned to the tm1e allele. Phenotypes include: decreased body weight, increased lactate dehydrogenase level, abnormal coping response, abnormal bone mineralization, increased circulating creatine kinase level & increased mean corpuscular volume. Contact
129-Foxa2<tm1Jrt>/H Homozygous lethal at day 8 of gestation. This mouse strain has a pre-disposition to develop mis-aligned jaws which leads to over grown teeth. Contact
129-Ncf1<tm1Hbd>/H Impaired innate immunity. Contact
129-Tgfbr2<tm1Roes>/RoesH Contact
129.C-Tg(Prnp/PRNP)1Drb 129-Prnp<tm1Cwe>/DrbH The octameric repeat region of the mouse prion protein was replaced with the hexameric repeat region from the domestic chicken. The mice express mouse PrP at wild-type levels with correct membrane location and orientation but have an altered metal binding region. The mice have been generated to get a better understanding of prion diseases such as CJD in humans. Contact
129.Cg-Pax6<Sey> Tg(Hbb-b1)83Clo/WsH Reiterated transgene is detectable by DNA in situ hybridisation. Contact
129.Cg-Tg(TetO-Gal)82Wyn/WynH Homozygotes have a reduction in neuropathic pain. Contact
129.Cg-Tgm2<tm1Gml> Apoe<tm1Bres>/CljH[cc] None. Contact
129P2-Gal<tm1Wyn>/WynH Developmental deficits in DRG and cholinergic neurons, absence of neuropathic pain, deficits in neuronal regeneration and neurite outgrowth and more severe disease in EAE model of MS and A-beta model of AD Contact
129P2/OlaHsd-Dynll1<Gt(EUCE0287d04)Hmgu>/H Potential EUMODIC data in the Europhenome database. Contact
129P2/OlaHsd-Rab18<Gt(EUCE0233a03)Hmgu>/H Full description available from Europhenome. Contact
129P2/OlaHsd-Wt1<tm1Mlh>/H Heterozygous mutant mice develop glomerulosclerosis (typical of Denys Drash Syndrome) with age. Contact

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