Stock

FESA Number

6457

Strain Name

STOCK 129-Rab27b<tm1.2Seab>/SeabH

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - Inbred strain

Attribution

Institution name Depositor / Originator Name
Imperial College Originator Retained
Imperial College Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Rab27b<tm1.2Seab> MGI:3706986 Rab27b MGI:1931295 18

Phenotypic Description

Mice exhibit significant haemorrhagic disease - platelets demonstrated impaired aggregation with collagen and U46619 and reduced secretion of dense granules. The number of dense granules per platelet serotonin content are also reduced. Mice are fertile, have normal life span, seems to be healthy, phenotypically look normal.

Publications

Displaying 1 - 4 of 4 Stock Publications
Pubmed ID Authors Title Journal
21160031 Bolasco G Loss of Rab27 function results in abnormal lung epithelium structure in mice. Am J Physiol Cell Physiol (2 011) 300:C466-76
21525430 Chiang L Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol (2 011) 301:C507-21
23281710 Singh RK Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion. FEBS J (2 013) 280:892-903
17384153 Tolmachova T Rab27b regulates number and secretion of platelet dense granules. Proc Natl Acad Sci U S A (2 007) 104:5872-7

Human Disease Links

storage pool platelet disease

EMMA ID

EM:07825

Genetic Status

GMO

Background Strain Name

C57BL/6

Background Strain MGI ID

MGI:2159769

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