Stock

FESA Number

6525

Strain Name

SJL/J Lgals3tm1Poi

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Lgals3<tm1Poi> MGI:2183057 Lgals3 MGI:96778 14

Phenotypic Description

These mice are susceptible to Theilers Murine Encephalomyelitis Virus infection and can be used to model primary progressive multiple sclerosis. During the backcrossing there was high mortality rate amongst litters and very poor breeding due to aversion to other mouse strain pheromones. SJL/J males also exhibited significant aggression often resulting in amyloidosis (sequel of social submissiveness and consequent wounds) in female breeding partners which were often severe and required culling.

Publications

Displaying 1 - 10 of 30 Stock Publications
Pubmed ID Authors Title Journal
23563688 Bermejo DA Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors ROR?t and Ahr that leads to IL-17 production by activated B cells. Nat Immunol (2 013) 14:514-22
18202187 Henderson NC Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis. Am J Pathol (2 008) 172:288-98
23115194 Bischoff V Seizure-induced neuronal death is suppressed in the absence of the endogenous lectin Galectin-1. J Neurosci (2 012) 32:15590-600
16549783 Henderson NC Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Proc Natl Acad Sci U S A (2 006) 103:5060-5
17785480 Breuilh L Galectin-3 modulates immune and inflammatory responses during helminthic infection: impact of galectin-3 deficiency on the functions of dendritic cells. Infect Immun (2 007) 75:5148-57
22836271 Lalancette-Hébert M Galectin-3 is required for resident microglia activation and proliferation in response to ischemic injury. J Neurosci (2 012) 32:10383-95
23117656 Calvier L Galectin-3 mediates aldosterone-induced vascular fibrosis. Arterioscler Thromb Vasc Biol (2 013) 33:67-75
18250477 MacKinnon AC Regulation of alternative macrophage activation by galectin-3. J Immunol (2 008) 180:2650-8
17148658 Chiu MG Galectin-3 associates with the primary cilium and modulates cyst growth in congenital polycystic kidney disease. Am J Pathol (2 006) 169:1925-38
23527230 Mishra BB Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia. PLoS One (2 013) 8:e59616

Pages

EMMA ID

EM:07422

Contact/Order

For more information or to order stocks, Contact us