Stock

FESA Number

4506

Strain Name

B6.Cg-Ndrg1<str>/H

Mutation Strain Type

Attribution

Institution name Depositor / Originator Name
University College London Originator Retained
University College London Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Ndrg1<str> MGI:5009138 15

Phenotypic Description

Mice at first develop normally but around the age of 5-6 weeks develop a peripheral demyelinating neuropathy resulting in weakness of the hind limbs. This manifests as clasping hind legs when suspended by tail, marked tremour, inability to maintain normal posture. Signs progress rapidly at first, stabilize after 20 weeks.

Orphanet Disorders

OrphaNet ID Name Url
99 950 Charcot-Marie-Tooth disease type 4D http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=99950

Publications

Orphanet Categories

Rare neurologic disease

EMMA ID

EM:05263

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