Stock
FESA Number
4506
Strain Name
B6.Cg-Ndrg1<str>/H
Mutation Strain Type
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| University College London | Originator | Retained |
| University College London | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Ndrg1<str> | MGI:5009138 | 15 |
Phenotypic Description
Mice at first develop normally but around the age of 5-6 weeks develop a peripheral demyelinating neuropathy resulting in weakness of the hind limbs. This manifests as clasping hind legs when suspended by tail, marked tremour, inability to maintain normal posture. Signs progress rapidly at first, stabilize after 20 weeks.
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 99 950 | Charcot-Marie-Tooth disease type 4D | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=99950 |
Publications
Orphanet Categories
Rare neurologic disease
EMMA ID
EM:05263
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