Stock B6.Cg-Ddx5<tm1.1Arte> Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/H

FESA Number

5618

Strain Name

B6.Cg-Ddx5<tm1.1Arte> Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation - Conditional IMSR - congenic strain

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained
Unknown Institution Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Gt(ROSA)26Sor<tm9(cre/ESR1)Arte> MGI:3763211 Gt(ROSA)26Sor MGI:104735 6
Ddx5<tm1.1Arte> MGI:5463981 Ddx5 MGI:105037 11

Phenotypic Description

Mouse strain has no detectable phenotype in the absence of activated Cre. Tamoxifen treatment induces p68 knockout in multiple tissues; this results in hypoplastic bone marrow and alterations in tissue organisation in the large intestine of a high proportion of mice. However, we have only been able to perform short term experiments. These mice would be ideal for the generation of tissue-specific p68 knockout models.

Publications

Displaying 1 - 10 of 75 Stock Publications
Pubmed ID Authors Title Journal
18690222 Ananieva O The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol (2 008) 9:1028-36
22269950 Hisada K RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells. Mol Cell Biol (2 012) 32:1139-49
24498102 Nagamachi A Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function. PLoS One (2 014) 9:e87425
24576537 Saba R CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways. Dev Biol (2 014) 389:173-81
20005806 Uhlenhaut NH Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell (2 009) 139:1130-42
20808952 Andreu-Vieyra CV MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing. PLoS Biol (2 010) 8:
24446488 Hu J Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid. J Exp Med (2 014) 211:281-95
20562878 Natoli TA Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models. Nat Med (2 010) 16:788-92
19729436 Sabbagh Y Intestinal npt2b plays a major role in phosphate absorption and homeostasis. J Am Soc Nephrol (2 009) 20:2348-58
22896614 Vaillancourt FH Evaluation of phosphatidylinositol-4-kinase III? as a hepatitis C virus drug target. J Virol (2 012) 86:11595-607

Pages

EMMA ID

EM:06817

Genetic Status

GMO

Production Information

Cre-Lox Recombination based excision

Background Strain Name

C57BL/6J

Background Strain MGI ID

MGI:3028467

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