Stock B6;129S4-Rhog<tm1Tnr>/H

FESA Number


Strain Name


Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - unclassified


Institution name Depositor / Originator Name
Babraham Institute Originator Retained
Babraham Institute Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Rhog<tm1Tnr> MGI:3029009 Rhog MGI:1928370 7

Phenotypic Description

Mild hyper reactivity of lymphocytes to antigen receptor engagement.


Displaying 1 - 9 of 9 Stock Publications
Pubmed ID Authors Title Journal
17898204 Backer S Trio controls the mature organization of neuronal clusters in the hindbrain. J Neurosci (2 007) 27:10323-32
21982645 Bass MD A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis. Dev Cell (2 011) 21:681-93
16621998 Condliffe AM RhoG regulates the neutrophil NADPH oxidase. J Immunol (2 006) 176:5314-20
24659802 Damoulakis G P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils. J Cell Sci (2 014) 127:2589-600
24106270 Goggs R RhoG protein regulates platelet granule secretion and thrombus formation in mice. J Biol Chem (2 013) 288:34217-29
24106269 Kim S RhoG protein regulates glycoprotein VI-Fc receptor ?-chain complex-mediated platelet activation and thrombus formation. J Biol Chem (2 013) 288:34230-8
21820331 Martínez-Martín N T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis. Immunity (2 011) 35:208-22
20038798 Sauzeau V The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells. J Clin Invest (2 010) 120:315-30
14701744 Vigorito E Immunological function in mice lacking the Rac-related GTPase RhoG. Mol Cell Biol (2 004) 24:719-29




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