Stock B6.129S-Tectb<tm1Gpr>/H

FESA Number

4846

Strain Name

B6.129S-Tectb<tm1Gpr>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation - Knock out IMSR - congenic strain

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Tectb<tm1Gpr> MGI:3711698 Tectb MGI:109574 19

Severity Limit

Mild

Phenotypic Description

Homozygous mutant mice suffer low frequency hearing loss and have normally attached tectorial membranes that lack striated sheet matrix. Hensen's stripe is missing and the marginal band is absent in the apical coil of the cochlea. Sharpness of high frequency tuning is enhanced.

Publications

Displaying 1 - 2 of 2 Stock Publications
Pubmed ID Authors Title Journal
20981024 Ghaffari R Tectorial membrane travelling waves underlie abnormal hearing in Tectb mutant mice. Nat Commun (2 010) 1:96
17220887 Russell IJ Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane. Nat Neurosci (2 007) 10:215-23

EMMA ID

EM:05540

Genetic Status

GMO

Background Strain Name

C57BL/6J

Background Strain MGI ID

MGI:3028467

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