Stock
FESA Number
3538
Strain Name
B6.129P2-Scn10a<tm1Jnw>/JnwH
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Targeted mutation | IMSR - unclassified |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| University College London | Originator | Retained |
| University College London | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Scn10a<tm1Jnw> | MGI:2180183 | Scn10a | MGI:108029 | 9 |
Phenotypic Description
Defects in mechanical and inflammatory pain tests.
Publications
Displaying 1 - 10 of 16 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 18669863 | Abrahamsen B | The cell and molecular basis of mechanical, cold, and inflammatory pain. | Science (2 008) 321:702-5 |
| 10448219 | Akopian AN | The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. | Nat Neurosci (1 999) 2:541-8 |
| 20062061 | Chambers JC | Genetic variation in SCN10A influences cardiac conduction. | Nat Genet (2 010) 42:149-52 |
| 23575686 | Eijkelkamp N | A role for Piezo2 in EPAC1-dependent mechanical allodynia. | Nat Commun (2 013) 4:1682 |
| 11568640 | Kerr BJ | A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain. | Neuroreport (2 001) 12:3077-80 |
| 12351708 | Laird JM | Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice. | J Neurosci (2 002) 22:8352-6 |
| 24440715 | Minett MS | Pain without nociceptors? Nav1.7-independent pain mechanisms. | Cell Rep (2 014) 6:301-12 |
| 22531176 | Minett MS | Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. | Nat Commun (2 012) 3:791 |
| 11495938 | Renganathan M | Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons. | J Neurophysiol (2 001) 86:629-40 |
| 10938298 | Renganathan M | alpha-SNS produces the slow TTX-resistant sodium current in large cutaneous afferent DRG neurons. | J Neurophysiol (2 000) 84:710-8 |
Pages
EMMA ID
EM:02290
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