Stock B6.129P2-Scn10a<tm1Jnw>/JnwH

FESA Number

3538

Strain Name

B6.129P2-Scn10a<tm1Jnw>/JnwH

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - unclassified

Attribution

Institution name Depositor / Originator Name
University College London Originator Retained
University College London Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Scn10a<tm1Jnw> MGI:2180183 Scn10a MGI:108029 9

Phenotypic Description

Defects in mechanical and inflammatory pain tests.

Publications

Displaying 1 - 10 of 16 Stock Publications
Pubmed ID Authors Title Journal
18669863 Abrahamsen B The cell and molecular basis of mechanical, cold, and inflammatory pain. Science (2 008) 321:702-5
10448219 Akopian AN The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci (1 999) 2:541-8
20062061 Chambers JC Genetic variation in SCN10A influences cardiac conduction. Nat Genet (2 010) 42:149-52
23575686 Eijkelkamp N A role for Piezo2 in EPAC1-dependent mechanical allodynia. Nat Commun (2 013) 4:1682
11568640 Kerr BJ A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain. Neuroreport (2 001) 12:3077-80
12351708 Laird JM Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice. J Neurosci (2 002) 22:8352-6
24440715 Minett MS Pain without nociceptors? Nav1.7-independent pain mechanisms. Cell Rep (2 014) 6:301-12
22531176 Minett MS Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. Nat Commun (2 012) 3:791
11495938 Renganathan M Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons. J Neurophysiol (2 001) 86:629-40
10938298 Renganathan M alpha-SNS produces the slow TTX-resistant sodium current in large cutaneous afferent DRG neurons. J Neurophysiol (2 000) 84:710-8

Pages

EMMA ID

EM:02290

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