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Stock B6;129-Gt(ROSA)26Sor<tm1(CAG-Venus/GMNN,Cherry/CDT1)Jkn>/JknH

FESA Number

6899

Strain Name

B6;129-Gt(ROSA)26Sor<tm1(CAG-Venus/GMNN,Cherry/CDT1)Jkn>/JknH

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Gt(ROSA)26Sor<tm1(CAG-Venus/GMNN,-Cherry/CDT1)Jkn> MGI:5645798 Gt(ROSA)26Sor MGI:104735 6

Phenotypic Description

The Fucci system was developed by fusing red- and green-emitting fluorescent proteins to the E3 ligase substrates, Cdt1 and Geminin. These fluorescent probes make it possible to distinguish between cells in the G1 or S/G2/M phases of the cell cycle in live cells/tissue (Sakaue-Sawano al 2008). Fucci2a is a bicistronic version of Fucci2 allowing Cre-mediated tissue-specific expression in mice (Mort, R et al 2014).

Publications

Displaying 61 - 70 of 88 Stock Publications
Pubmed ID Authors Title Journal
11471054 Kohlhepp RL The ROSA26 LacZ-neo(R) insertion confers resistance to mammary tumors in Apc(Min/+) mice. Mamm Genome (2 001) 12:606-11
18997819 Parisi T Inhibition of pituitary tumors in Rb mutant chimeras through E2f4 loss reveals a key suppressive role for the pRB/E2F pathway in urothelium and ganglionic carcinogenesis. Oncogene (2 009) 28:500-8
15867156 Vidal A p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow. Proc Natl Acad Sci U S A (2 005) 102:6890-5
19834060 Bianco C Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells. Am J Pathol (2 009) 175:2146-58
1653172 Friedrich G Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev (1 991) 5:1513-23
19369648 Kubota H Spermatogonial stem cells derived from infertile Wv/Wv mice self-renew in vitro and generate progeny following transplantation. Biol Reprod (2 009) 81:293-301
18263895 Patel V Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet (2 008) 17:1578-90
12435628 Wijgerde M A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev (2 002) 16:2849-64
16887830 Bosman EA Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels. Development (2 006) 133:3399-409
10498279 Gitton Y Role of thalamic axons in the expression of H-2Z1, a mouse somatosensory cortex specific marker. Cereb Cortex (1 999) 9:611-20

Pages

EMMA ID

EM:08395

Genetic Status

GMO

Background Strain Name

C57BL/6

Background Strain MGI ID

MGI:2159769

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