Stock

FESA Number

7784

Strain Name

B6;129-Anxa6<tm1Moss>

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant stock

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained
Unknown Institution Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Anxa6<tm1Moss> MGI:2159012 Anxa6 MGI:88255 11

Phenotypic Description

Homozygotes have altered mechanical and intracellular calcium signalling in cardiomyocytes. They display altered regulation of mitochondrial morphogenesis. Western blot studies indicate that no detectable protein is produced. Original chimaeric mouse was crossed to C57BL/6 then strain has been maintained by sib crossing for 20 generations.

Publications

Displaying 1 - 6 of 6 Stock Publications
Pubmed ID Authors Title Journal
19580468 Belluoccio D Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization. J Bone Miner Res (2 010) 25:141-53
23341998 Chlystun M Regulation of mitochondrial morphogenesis by annexin A6. PLoS One (2 013) 8:e53774
22692895 Grskovic I Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle-mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response. J Bone Miner Res (2 012) 27:2399-412
10567528 Hawkins TE Immunological development and cardiovascular function are normal in annexin VI null mutant mice. Mol Cell Biol (1 999) 19:8028-32
22399299 Minashima T Intracellular modulation of signaling pathways by annexin A6 regulates terminal differentiation of chondrocytes. J Biol Chem (2 012) 287:14803-15
11919174 Song G Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice. FASEB J (2 002) 16:622-4

EMMA ID

EM:09630

Genetic Status

GMO

Background Strain Name

C57BL/6

Background Strain MGI ID

MGI:2159769

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