Stock 129S2.Cg-Tg(KRT10-Igfr2*)KippsGfc/H

FESA Number

3546

Strain Name

129S2.Cg-Tg(KRT10-Igfr2*)KippsGfc/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Transgenic IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
University of Oxford Originator Retained
University of Oxford Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Tg(KRT10-Igf2r*)KippsGfc MGI:5436057

Phenotypic Description

Slightly reduced overall body weight, disproportionate reduction in size of alimentary canal and uterus.

Publications

Displaying 1 - 3 of 3 Stock Publications
Pubmed ID Authors Title Journal
16488992 Harper J Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting. Cancer Res (2 006) 66:1940-8
9724044 Zaina S Local reduction of organ size in transgenic mice expressing a soluble insulin-like growth factor II/mannose-6-phosphate receptor. Endocrinology (1 998) 139:3886-95
9786853 Zaina S The soluble type 2 insulin-like growth factor (IGF-II) receptor reduces organ size by IGF-II-mediated and IGF-II-independent mechanisms. J Biol Chem (1 998) 273:28610-6

EMMA ID

EM:04336

Background Strain Name

129S2/SvPas

Background Strain MGI ID

MGI:2161070

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