Stock 129P2/OlaHsdH-Prnp<tm2Edin>/H

FESA Number

59

Strain Name

129P2/OlaHsdH-Prnp<tm2Edin>/H

Mutation Strain Type

Attribution

Institution name Depositor / Originator Name
Institute for Animal Health Originator Retained
Institute for Animal Health Depositor Retained

Phenotypic Description

No expression of the Prnp gene. Abnormalities in synaptic transmission, circadian rhythm and sleep. Increased susceptability to oxidative stress and copper toxicity. Cellular phenotypes in T cell activation.

Orphanet Disorders

OrphaNet ID Name Url
356 Gerstmann-Straussler-Scheinker syndrome http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=356
466 Fatal familial insomnia http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=466
157 941 Huntington disease-like 1 http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=157941
280 397 Familial Alzheimer-like prion disease http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=280397
282 166 Inherited Creutzfeldt-Jakob disease http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=282166

Publications

Orphanet Categories

Rare neurologic disease

EMMA ID

EM:01719

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