Stock 129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

FESA Number

2899

Strain Name

129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Serpine1<tm1Mlg> MGI:1857287 Serpine1 MGI:97608 5

Phenotypic Description

Shortened life span.

Orphanet Disorders

OrphaNet ID Name Url
465 Congenital plasminogen activator inhibitor type 1 deficiency http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465

Publications

Displaying 71 - 80 of 229 Stock Publications
Pubmed ID Authors Title Journal
23254194 Kenny S Gastric expression of plasminogen activator inhibitor (PAI)-1 is associated with hyperphagia and obesity in mice. Endocrinology (2 013) 154:718-26
18753414 Maillard CM Reduction of brain metastases in plasminogen activator inhibitor-1-deficient mice with transgenic ocular tumors. Carcinogenesis (2 008) 29:2236-42
12074598 Oh CK PAI-1 promotes extracellular matrix deposition in the airways of a murine asthma model. Biochem Biophys Res Commun (2 002) 294:1155-60
17067365 Scroyen I No functional role of plasminogen activator inhibitor-1 in murine adipogenesis or adipocyte differentiation. J Thromb Haemost (2 007) 5:139-45
21622848 Zmijewski JW Inhibition of neutrophil apoptosis by PAI-1. Am J Physiol Lung Cell Mol Physiol (2 011) 301:L247-54
9861024 Bergeron N Lamellar lipoproteins uniquely contribute to hyperlipidemia in mice doubly deficient in apolipoprotein E and hepatic lipase. Proc Natl Acad Sci U S A (1 998) 95:15647-52
10441168 George J The involvement of beta2-glycoprotein I (beta2-GPI) in human and murine atherosclerosis. J Autoimmun (1 999) 13:57-60
15781753 Johnson J Plaque rupture after short periods of fat feeding in the apolipoprotein E-knockout mouse: model characterization and effects of pravastatin treatment. Circulation (2 005) 111:1422-30
16816382 Liu H Reduced acute vascular injury and atherosclerosis in hyperlipidemic mice transgenic for lysozyme. Am J Pathol (2 006) 169:303-13
14688198 Poch E Short telomeres protect from diet-induced atherosclerosis in apolipoprotein E-null mice. FASEB J (2 004) 18:418-20

Pages

Orphanet Categories

Rare hematologic disease

EMMA ID

EM:02066

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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