Stock 129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

FESA Number

2899

Strain Name

129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Serpine1<tm1Mlg> MGI:1857287 Serpine1 MGI:97608 5

Phenotypic Description

Shortened life span.

Orphanet Disorders

OrphaNet ID Name Url
465 Congenital plasminogen activator inhibitor type 1 deficiency http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465

Publications

Displaying 61 - 70 of 229 Stock Publications
Pubmed ID Authors Title Journal
17215360 Amirbekian V Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI. Proc Natl Acad Sci U S A (2 007) 104:961-6
7829881 Feingold KR Apolipoprotein E deficiency leads to cutaneous foam cell formation in mice. J Invest Dermatol (1 995) 104:246-50
11433351 Jiang XC Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat Med (2 001) 7:847-52
10487844 Licastro F A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease. Am J Pathol (1 999) 155:869-75
7937814 Plump AS Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci U S A (1 994) 91:9607-11
7667279 Smith JD Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci U S A (1 995) 92:8264-8
12006391 Williams H Characteristics of intact and ruptured atherosclerotic plaques in brachiocephalic arteries of apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol (2 002) 22:788-92
15286708 Bajou K Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth. Oncogene (2 004) 23:6986-90
16735799 Collins SJ Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice. Nephron Exp Nephrol (2 006) 104:e23-34
11059781 Gutierrez LS Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1. Cancer Res (2 000) 60:5839-47

Pages

Orphanet Categories

Rare hematologic disease

EMMA ID

EM:02066

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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