Stock 129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

FESA Number

2899

Strain Name

129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Serpine1<tm1Mlg> MGI:1857287 Serpine1 MGI:97608 5

Phenotypic Description

Shortened life span.

Orphanet Disorders

OrphaNet ID Name Url
465 Congenital plasminogen activator inhibitor type 1 deficiency http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465

Publications

Displaying 51 - 60 of 229 Stock Publications
Pubmed ID Authors Title Journal
16518689 Smith JD Transcriptome profile of macrophages from atherosclerosis-sensitive and atherosclerosis-resistant mice. Mamm Genome (2 006) 17:220-9
17967778 Westerterp M Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice. Circulation (2 007) 116:2173-81
9701244 Bajou K Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization. Nat Med (1 998) 4:923-8
12875966 Chuang-Tsai S Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1. Am J Pathol (2 003) 163:445-52
23724005 Ghosh AK Global gene expression profiling in PAI-1 knockout murine heart and kidney: molecular basis of cardiac-selective fibrosis. PLoS One (2 013) 8:e63825
23494120 Kenny S The role of plasminogen activator inhibitor-1 in gastric mucosal protection. Am J Physiol Gastrointest Liver Physiol (2 013) 304:G814-22
11884297 Luttun A Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2 002) 22:499-505
11473641 Oda T PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction. Kidney Int (2 001) 60:587-96
11481248 Schäfer K Disruption of the plasminogen activator inhibitor 1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice. FASEB J (2 001) 15:1840-2
10368124 Zhu Y Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance. Circulation (1 999) 99:3050-5

Pages

Orphanet Categories

Rare hematologic disease

EMMA ID

EM:02066

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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