Stock 129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

FESA Number

2899

Strain Name

129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - unclassified

Attribution

Institution name Depositor / Originator Name
University of Bristol Originator Retained
University of Bristol Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Serpine1<tm1Mlg> MGI:1857287 Serpine1 MGI:97608 5

Phenotypic Description

Shortened life span.

Orphanet Disorders

OrphaNet ID Name Url
465 Congenital plasminogen activator inhibitor type 1 deficiency http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465

Publications

Displaying 1 - 10 of 229 Stock Publications
Pubmed ID Authors Title Journal
10192911 Adan Y Concentration of serum lipids and aortic lesion size in female and male apo E-deficient mice fed docosahexaenoic acid. Biosci Biotechnol Biochem (1 999) 63:309-13
10484545 Deckert V Impairment of endothelium-dependent arterial relaxation by high-fat feeding in ApoE-deficient mice: toward normalization by human ApoA-I expression. Circulation (1 999) 100:1230-5
11160157 Hodgin JB Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice. J Clin Invest (2 001) 107:333-40
16100042 Lee K Alterations in internal elastic lamina permeability as a function of age and anatomical site precede lesion development in apolipoprotein E-null mice. Circ Res (2 005) 97:450-6
8527231 Plump AS Apolipoprotein E and the apolipoprotein E-deficient mouse. Annu Rev Nutr (1 995) 15:495-518
21571684 Shim J Genetic susceptibility of the arterial wall is an important determinant of atherosclerosis in C57BL/6 and FVB/N mouse strains. Arterioscler Thromb Vasc Biol (2 011) 31:1814-20
20952520 Wang B miR-200a Prevents renal fibrogenesis through repression of TGF-?2 expression. Diabetes (2 011) 60:280-7
22213800 Ardite E PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy. J Cell Biol (2 012) 196:163-75
8254029 Carmeliet P Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis. J Clin Invest (1 993) 92:2756-60
22984202 Fang H Protumorigenic activity of plasminogen activator inhibitor-1 through an antiapoptotic function. J Natl Cancer Inst (2 012) 104:1470-84

Pages

Orphanet Categories

Rare hematologic disease

EMMA ID

EM:02066

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

Contact/Order

For more information or to order stocks, Contact us