Stock

FESA Number

2900

Strain Name

129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Plg<tm1Jld> MGI:1857291 Plg MGI:97620 17

Phenotypic Description

Rectal prolapse. Shortened life span in homozygotes.

Orphanet Disorders

Publications

Displaying 41 - 50 of 171 Stock Publications
Pubmed ID Authors Title Journal
7705657 Bugge TH Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes Dev (1 995) 9:794-807
18371407 Heissig B The plasminogen fibrinolytic pathway is required for hematopoietic regeneration. Cell Stem Cell (2 007) 1:658-70
17395831 Passino MA Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR. Science (2 007) 315:1853-6
8987777 Tsirka SE An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J Neurosci (1 997) 17:543-52
17215360 Amirbekian V Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI. Proc Natl Acad Sci U S A (2 007) 104:961-6
7829881 Feingold KR Apolipoprotein E deficiency leads to cutaneous foam cell formation in mice. J Invest Dermatol (1 995) 104:246-50
11433351 Jiang XC Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat Med (2 001) 7:847-52
10487844 Licastro F A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease. Am J Pathol (1 999) 155:869-75
7937814 Plump AS Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci U S A (1 994) 91:9607-11
7667279 Smith JD Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci U S A (1 995) 92:8264-8

Pages

Orphanet Categories

Rare systemic or rheumatologic disease
Rare eye disease

EMMA ID

EM:02065

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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