Stock

FESA Number

2900

Strain Name

129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Plg<tm1Jld> MGI:1857291 Plg MGI:97620 17

Phenotypic Description

Rectal prolapse. Shortened life span in homozygotes.

Orphanet Disorders

Publications

Displaying 31 - 40 of 171 Stock Publications
Pubmed ID Authors Title Journal
22815383 Hald A Plasmin-driven fibrinolysis facilitates skin tumor growth in a gender-dependent manner. FASEB J (2 012) 26:4445-57
15486301 Pang PT Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science (2 004) 306:487-91
16554301 Stempien-Otero A Mechanisms of cardiac fibrosis induced by urokinase plasminogen activator. J Biol Chem (2 006) 281:15345-51
22469977 Alikhani N Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model. Oncogene (2 013) 32:961-7
21041949 Feig JE LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. J Clin Invest (2 010) 120:4415-24
9466986 Jeong Ts Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase. J Clin Invest (1 998) 101:905-12
19959238 Lewis RD The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice. Mol Immunol (2 010) 47:1098-105
8647961 Plump AS Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production. J Clin Invest (1 996) 97:2660-71
16518689 Smith JD Transcriptome profile of macrophages from atherosclerosis-sensitive and atherosclerosis-resistant mice. Mamm Genome (2 006) 17:220-9
17967778 Westerterp M Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice. Circulation (2 007) 116:2173-81

Pages

Orphanet Categories

Rare systemic or rheumatologic disease
Rare eye disease

EMMA ID

EM:02065

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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