Stock
FESA Number
2900
Strain Name
129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]
Mutation Strain Type
Attribution
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Apoe<tm1Bres> | MGI:2137814 | Apoe | MGI:88057 | 7 |
| Plg<tm1Jld> | MGI:1857291 | Plg | MGI:97620 | 17 |
Phenotypic Description
Rectal prolapse. Shortened life span in homozygotes.
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 722 | Hypoplasminogenemia | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=722 |
| 97 231 | Ligneous conjunctivitis | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=97231 |
Publications
Displaying 31 - 40 of 171 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 22815383 | Hald A | Plasmin-driven fibrinolysis facilitates skin tumor growth in a gender-dependent manner. | FASEB J (2 012) 26:4445-57 |
| 15486301 | Pang PT | Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. | Science (2 004) 306:487-91 |
| 16554301 | Stempien-Otero A | Mechanisms of cardiac fibrosis induced by urokinase plasminogen activator. | J Biol Chem (2 006) 281:15345-51 |
| 22469977 | Alikhani N | Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model. | Oncogene (2 013) 32:961-7 |
| 21041949 | Feig JE | LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. | J Clin Invest (2 010) 120:4415-24 |
| 9466986 | Jeong Ts | Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase. | J Clin Invest (1 998) 101:905-12 |
| 19959238 | Lewis RD | The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice. | Mol Immunol (2 010) 47:1098-105 |
| 8647961 | Plump AS | Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production. | J Clin Invest (1 996) 97:2660-71 |
| 16518689 | Smith JD | Transcriptome profile of macrophages from atherosclerosis-sensitive and atherosclerosis-resistant mice. | Mamm Genome (2 006) 17:220-9 |
| 17967778 | Westerterp M | Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice. | Circulation (2 007) 116:2173-81 |
Pages
Orphanet Categories
Rare systemic or rheumatologic disease
Rare eye disease
EMMA ID
EM:02065
Genetic Status
GMO
Background Strain Name
129
Background Strain MGI ID
MGI:2160041
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