Stock 129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]
FESA Number
2900
Strain Name
129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]
Mutation Strain Type
Attribution
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Apoe<tm1Bres> | MGI:2137814 | Apoe | MGI:88057 | 7 |
| Plg<tm1Jld> | MGI:1857291 | Plg | MGI:97620 | 17 |
Phenotypic Description
Rectal prolapse. Shortened life span in homozygotes.
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 722 | Hypoplasminogenemia | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=722 |
| 97 231 | Ligneous conjunctivitis | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=97231 |
Publications
Displaying 21 - 30 of 171 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 17431190 | Otsuka G | Mechanisms of TGF-beta1-induced intimal growth: plasminogen-independent activities of plasminogen activator inhibitor-1 and heterogeneous origin of intimal cells. | Circ Res (2 007) 100:1300-7 |
| 11404420 | Siconolfi LB | Mice lacking tPA, uPA, or plasminogen genes showed delayed functional recovery after sciatic nerve crush. | J Neurosci (2 001) 21:4348-55 |
| 1712312 | Agarwal N | Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2). | Exp Eye Res (1 991) 52:549-61 |
| 9555870 | de Villiers WJ | Macrophage phenotype in mice deficient in both macrophage-colony-stimulating factor (op) and apolipoprotein E. | Arterioscler Thromb Vasc Biol (1 998) 18:631-40 |
| 14614151 | Idel S | A20, a regulator of NFkappaB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains. | Proc Natl Acad Sci U S A (2 003) 100:14235-40 |
| 12569158 | Lesnik P | Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis. | J Clin Invest (2 003) 111:333-40 |
| 1423598 | Plump AS | Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. | Cell (1 992) 71:343-53 |
| 11988491 | Silence J | Reduced atherosclerotic plaque but enhanced aneurysm formation in mice with inactivation of the tissue inhibitor of metalloproteinase-1 (TIMP-1) gene. | Circ Res (2 002) 90:897-903 |
| 8962133 | Weng W | Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility. | Proc Natl Acad Sci U S A (1 996) 93:14788-94 |
| 8929539 | Bugge TH | Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency. | Cell (1 996) 87:709-19 |
Pages
Orphanet Categories
Rare systemic or rheumatologic disease
Rare eye disease
EMMA ID
EM:02065
Genetic Status
GMO
Background Strain Name
129
Background Strain MGI ID
MGI:2160041
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