Stock

FESA Number

2900

Strain Name

129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Plg<tm1Jld> MGI:1857291 Plg MGI:97620 17

Phenotypic Description

Rectal prolapse. Shortened life span in homozygotes.

Orphanet Disorders

Publications

Displaying 101 - 110 of 171 Stock Publications
Pubmed ID Authors Title Journal
7802634 Hayek T Role of HDL apolipoprotein E in cellular cholesterol efflux: studies in apo E knockout transgenic mice. Biochem Biophys Res Commun (1 994) 205:1072-8
21372295 Katsume A Early inflammatory reactions in atherosclerosis are induced by proline-rich tyrosine kinase/reactive oxygen species-mediated release of tumor necrosis factor-alpha and subsequent activation of the p21Cip1/Ets-1/p300 system. Arterioscler Thromb Vasc Biol (2 011) 31:1084-92
8550828 Masucci-Magoulas L Profound induction of hepatic cholesteryl ester transfer protein transgene expression in apolipoprotein E and low density lipoprotein receptor gene knockout mice. A novel mechanism signals changes in plasma cholesterol levels. J Clin Invest (1 996) 97:154-61
11705823 Rong JX Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content. Circulation (2 001) 104:2447-52
19416717 Thorp E Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab (2 009) 9:474-81
10559023 Yang R Hypertension and endothelial dysfunction in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol (1 999) 19:2762-8
15545316 Chun TH MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix. J Cell Biol (2 004) 167:757-67
24732409 Liu Z Plasminogen deficiency causes reduced corticospinal axonal plasticity and functional recovery after stroke in mice. PLoS One (2 014) 9:e94505
8612226 Romer J Impaired wound healing in mice with a disrupted plasminogen gene. Nat Med (1 996) 2:287-92
17267741 Zhang G Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals. J Am Soc Nephrol (2 007) 18:846-59

Pages

Orphanet Categories

Rare systemic or rheumatologic disease
Rare eye disease

EMMA ID

EM:02065

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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