Stock
FESA Number
2900
Strain Name
129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Targeted mutation | IMSR - congenic strain |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| University of Bristol | Originator | Retained |
| University of Bristol | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Apoe<tm1Bres> | MGI:2137814 | Apoe | MGI:88057 | 7 |
| Plg<tm1Jld> | MGI:1857291 | Plg | MGI:97620 | 17 |
Phenotypic Description
Rectal prolapse. Shortened life span in homozygotes.
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 722 | Hypoplasminogenemia | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=722 |
| 97 231 | Ligneous conjunctivitis | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=97231 |
Publications
Displaying 1 - 10 of 171 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 10192911 | Adan Y | Concentration of serum lipids and aortic lesion size in female and male apo E-deficient mice fed docosahexaenoic acid. | Biosci Biotechnol Biochem (1 999) 63:309-13 |
| 10484545 | Deckert V | Impairment of endothelium-dependent arterial relaxation by high-fat feeding in ApoE-deficient mice: toward normalization by human ApoA-I expression. | Circulation (1 999) 100:1230-5 |
| 11160157 | Hodgin JB | Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice. | J Clin Invest (2 001) 107:333-40 |
| 16100042 | Lee K | Alterations in internal elastic lamina permeability as a function of age and anatomical site precede lesion development in apolipoprotein E-null mice. | Circ Res (2 005) 97:450-6 |
| 8527231 | Plump AS | Apolipoprotein E and the apolipoprotein E-deficient mouse. | Annu Rev Nutr (1 995) 15:495-518 |
| 21571684 | Shim J | Genetic susceptibility of the arterial wall is an important determinant of atherosclerosis in C57BL/6 and FVB/N mouse strains. | Arterioscler Thromb Vasc Biol (2 011) 31:1814-20 |
| 20952520 | Wang B | miR-200a Prevents renal fibrogenesis through repression of TGF-?2 expression. | Diabetes (2 011) 60:280-7 |
| 11557572 | Brodsky S | Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis. | Am J Physiol Heart Circ Physiol (2 001) 281:H1784-92 |
| 16949567 | Green KA | Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation. | Dev Biol (2 006) 299:164-75 |
| 22056679 | Okaji Y | Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis. | Exp Hematol (2 012) 40:143-54 |
Pages
Orphanet Categories
Rare systemic or rheumatologic disease
Rare eye disease
EMMA ID
EM:02065
Genetic Status
GMO
Background Strain Name
129
Background Strain MGI ID
MGI:2160041
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