Stock 129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]

FESA Number

2900

Strain Name

129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - congenic strain

Attribution

Institution name Depositor / Originator Name
University of Bristol Originator Retained
University of Bristol Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Plg<tm1Jld> MGI:1857291 Plg MGI:97620 17

Phenotypic Description

Rectal prolapse. Shortened life span in homozygotes.

Orphanet Disorders

Publications

Displaying 1 - 10 of 171 Stock Publications
Pubmed ID Authors Title Journal
10192911 Adan Y Concentration of serum lipids and aortic lesion size in female and male apo E-deficient mice fed docosahexaenoic acid. Biosci Biotechnol Biochem (1 999) 63:309-13
10484545 Deckert V Impairment of endothelium-dependent arterial relaxation by high-fat feeding in ApoE-deficient mice: toward normalization by human ApoA-I expression. Circulation (1 999) 100:1230-5
11160157 Hodgin JB Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice. J Clin Invest (2 001) 107:333-40
16100042 Lee K Alterations in internal elastic lamina permeability as a function of age and anatomical site precede lesion development in apolipoprotein E-null mice. Circ Res (2 005) 97:450-6
8527231 Plump AS Apolipoprotein E and the apolipoprotein E-deficient mouse. Annu Rev Nutr (1 995) 15:495-518
21571684 Shim J Genetic susceptibility of the arterial wall is an important determinant of atherosclerosis in C57BL/6 and FVB/N mouse strains. Arterioscler Thromb Vasc Biol (2 011) 31:1814-20
20952520 Wang B miR-200a Prevents renal fibrogenesis through repression of TGF-?2 expression. Diabetes (2 011) 60:280-7
11557572 Brodsky S Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis. Am J Physiol Heart Circ Physiol (2 001) 281:H1784-92
16949567 Green KA Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation. Dev Biol (2 006) 299:164-75
22056679 Okaji Y Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis. Exp Hematol (2 012) 40:143-54

Pages

Orphanet Categories

Rare systemic or rheumatologic disease
Rare eye disease

EMMA ID

EM:02065

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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