Stock 129-Ncf1<tm1Hbd>/H

FESA Number

1596

Strain Name

129-Ncf1<tm1Hbd>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
University College London Originator Retained
University College London Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Ncf1<tm1Hbd> MGI:3576788 Ncf1 MGI:97283 5

Phenotypic Description

Impaired innate immunity.

Publications

Displaying 1 - 5 of 5 Stock Publications
Pubmed ID Authors Title Journal
11544318 Fairbairn IP ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion. J Immunol (2 001) 167:3300-7
19608974 Fan LM Knockout of p47 phox uncovers a critical role of p40 phox in reactive oxygen species production in microvascular endothelial cells. Arterioscler Thromb Vasc Biol (2 009) 29:1651-6
11733538 Harbord M Ym1 is a neutrophil granule protein that crystallizes in p47phox-deficient mice. J Biol Chem (2 002) 277:5468-75
15743827 Li JM Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: role of p47phox phosphorylation and binding to TRAF4. Mol Cell Biol (2 005) 25:2320-30
15626477 Mitchison NA Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection. Immunol Lett (2 005) 97:63-7

EMMA ID

EM:00255

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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