Stock

FESA Number

1531

Strain Name

129-Ctsg<tm1.1Roes>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
University College London Originator Retained
University College London Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Ctsg<tm1.1Roes> MGI:2182170 Ctsg MGI:88563 14

Phenotypic Description

Mice deficient in Ctsg are susceptible to fungal infections, despite normal neutrophil development and recruitment.

Publications

Displaying 1 - 5 of 5 Stock Publications
Pubmed ID Authors Title Journal
19039769 Birkner K The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms. Eur J Immunol (2 008) 38:3395-410
21911460 Hahn I Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice. Infect Immun (2 011) 79:4893-901
23934850 Rafatian N Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol (2 013) 305:H1141-8
22461690 Steinwede K Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice. J Immunol (2 012) 188:4476-87
10714686 Tkalcevic J Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity (2 000) 12:201-10

EMMA ID

EM:00052

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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