Stock
FESA Number
1531
Strain Name
129-Ctsg<tm1.1Roes>/H
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Targeted mutation | IMSR - mutant strain |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| University College London | Originator | Retained |
| University College London | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Ctsg<tm1.1Roes> | MGI:2182170 | Ctsg | MGI:88563 | 14 |
Phenotypic Description
Mice deficient in Ctsg are susceptible to fungal infections, despite normal neutrophil development and recruitment.
Publications
Displaying 1 - 5 of 5 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 19039769 | Birkner K | The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms. | Eur J Immunol (2 008) 38:3395-410 |
| 21911460 | Hahn I | Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice. | Infect Immun (2 011) 79:4893-901 |
| 23934850 | Rafatian N | Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice. | Am J Physiol Heart Circ Physiol (2 013) 305:H1141-8 |
| 22461690 | Steinwede K | Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice. | J Immunol (2 012) 188:4476-87 |
| 10714686 | Tkalcevic J | Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. | Immunity (2 000) 12:201-10 |
EMMA ID
EM:00052
Genetic Status
GMO
Background Strain Name
129
Background Strain MGI ID
MGI:2160041
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