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| Imprinting Loci | Chromosome | Chromosomal Region | Expressed parental allele: maternal (M)/ paternal (P) | Name | ||
|---|---|---|---|---|---|---|
| Wt1 | 2 | M | Wilms tumor 1 homolog | |||
| Gene Synonyms | ||||||
| Wt-1 | ||||||
| Gene References | ||||||
| Brideau CM,Eilertson KE,Hagarman JA,Bustamante CD,Soloway PD Successful computational prediction of novel imprinted genes from epigenomic features. Molecular and cellular biology. 2010();30(13):3357-70 PUBMED | ||||||
| Christoffels VM,Grieskamp T,Norden J,Mommersteeg MT,Rudat C,Kispert A Tbx18 and the fate of epicardial progenitors. Nature. 2009();458(7240):E8-9; discussion E9-10 PUBMED | ||||||
| Barrionuevo F,Georg I,Scherthan H,Lécureuil C,Guillou F,Wegner M,Scherer G Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8. Developmental biology. 2009();327(2):301-12 PUBMED | ||||||
| Mahtab EA,Vicente-Steijn R,Hahurij ND,Jongbloed MR,Wisse LJ,DeRuiter MC,Uhrin P,Zaujec J,Binder BR,Schalij MJ,Poelmann RE,Gittenberger-de Groot AC Podoplanin deficient mice show a RhoA-related hypoplasia of the sinus venosus myocardium including the sinoatrial node. Developmental dynamics : an official publication of the American Association of Anatomists. 2009();238(1):183-93 PUBMED | ||||||
| Que J,Wilm B,Hasegawa H,Wang F,Bader D,Hogan BL Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. Proceedings of the National Academy of Sciences of the United States of America. 2008();105(43):16626-30 PUBMED | ||||||
| Korostylev A,Worzfeld T,Deng S,Friedel RH,Swiercz JM,Vodrazka P,Maier V,Hirschberg A,Ohoka Y,Inagaki S,Offermanns S,Kuner R A functional role for semaphorin 4D/plexin B1 interactions in epithelial branching morphogenesis during organogenesis. Development (Cambridge, England). 2008();135(20):3333-43 PUBMED | ||||||
| Pitera JE,Scambler PJ,Woolf AS Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. Human molecular genetics. 2008();17(24):3953-64 PUBMED | ||||||
| Gustin SE,Western PS,McClive PJ,Harley VR,Koopman PA,Sinclair AH Testis development, fertility, and survival in Ethanolamine kinase 2-deficient mice. Endocrinology. 2008();149(12):6176-86 PUBMED | ||||||
| Lavine KJ,Long F,Choi K,Smith C,Ornitz DM Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development. Development (Cambridge, England). 2008();135(18):3161-71 PUBMED | ||||||
| Show 198 more Gene References below | ||||||
| Zhou B,von Gise A,Ma Q,Rivera-Feliciano J,Pu WT Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium. Biochemical and biophysical research communications. 2008();375(3):450-3 PUBMED | ||||||
| Sridurongrit S,Larsson J,Schwartz R,Ruiz-Lozano P,Kaartinen V Signaling via the Tgf-beta type I receptor Alk5 in heart development. Developmental biology. 2008();322(1):208-18 PUBMED | ||||||
| Smith CA,Shoemaker CM,Roeszler KN,Queen J,Crews D,Sinclair AH Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian development. BMC developmental biology. 2008();8():72 PUBMED | ||||||
| Georgas K,Rumballe B,Wilkinson L,Chiu HS,Lesieur E,Gilbert T,Little MH Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney. Histochemistry and cell biology. 2008();130(5):927-42 PUBMED | ||||||
| Saburi S,Hester I,Fischer E,Pontoglio M,Eremina V,Gessler M,Quaggin SE,Harrison R,Mount R,McNeill H Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nature genetics. 2008();40(8):1010-5 PUBMED | ||||||
| Zhou B,Ma Q,Rajagopal S,Wu SM,Domian I,Rivera-Feliciano J,Jiang D,von Gise A,Ikeda S,Chien KR,Pu WT Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008();454(7200):109-13 PUBMED | ||||||
| Cai CL,Martin JC,Sun Y,Cui L,Wang L,Ouyang K,Yang L,Bu L,Liang X,Zhang X,Stallcup WB,Denton CP,McCulloch A,Chen J,Evans SM A myocardial lineage derives from Tbx18 epicardial cells. Nature. 2008();454(7200):104-8 PUBMED | ||||||
| Kirschner KM,Hagen P,Hussels CS,Ballmaier M,Scholz H,Dame C The Wilms' tumor suppressor Wt1 activates transcription of the erythropoietin receptor in hematopoietic progenitor cells. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008();22(8):2690-701 PUBMED | ||||||
| Chang H,Gao F,Guillou F,Taketo MM,Huff V,Behringer RR Wt1 negatively regulates beta-catenin signaling during testis development. Development (Cambridge, England). 2008();135(10):1875-85 PUBMED | ||||||
| Klattig J,Sierig R,Kruspe D,Makki MS,Englert C WT1-mediated gene regulation in early urogenital ridge development. Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation. 2007();1(4):238-54 PUBMED | ||||||
| Qiu F,Jiang H,Xiang M A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008();28(13):3392-403 PUBMED | ||||||
| Mahtab EA,Wijffels MC,Van Den Akker NM,Hahurij ND,Lie-Venema H,Wisse LJ,Deruiter MC,Uhrin P,Zaujec J,Binder BR,Schalij MJ,Poelmann RE,Gittenberger-De Groot AC Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development. Developmental dynamics : an official publication of the American Association of Anatomists. 2008();237(3):847-57 PUBMED | ||||||
| Kanasaki K,Kanda Y,Palmsten K,Tanjore H,Lee SB,Lebleu VS,Gattone VH,Kalluri R Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Developmental biology. 2008();313(2):584-93 PUBMED | ||||||
| Doné SC,Takemoto M,He L,Sun Y,Hultenby K,Betsholtz C,Tryggvason K Nephrin is involved in podocyte maturation but not survival during glomerular development. Kidney international. 2008();73(6):697-704 PUBMED | ||||||
| Patek CE,Brownstein DG,Fleming S,Wroe C,Rose L,Webb A,Berry RL,Devenney PS,Walker M,Maddocks OD,Lawrence NJ,Harrison DJ,Wood KM,Miles CG,Hooper ML Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396). Transgenic research. 2008();17(3):459-75 PUBMED | ||||||
| Ijpenberg A,Pérez-Pomares JM,Guadix JA,Carmona R,Portillo-Sánchez V,Macías D,Hohenstein P,Miles CM,Hastie ND,Muñoz-Chápuli R Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis. Developmental biology. 2007();312(1):157-70 PUBMED | ||||||
| van Loo PF,Mahtab EA,Wisse LJ,Hou J,Grosveld F,Suske G,Philipsen S,Gittenberger-de Groot AC Transcription factor Sp3 knockout mice display serious cardiac malformations. Molecular and cellular biology. 2007();27(24):8571-82 PUBMED | ||||||
| Kim BM,Miletich I,Mao J,McMahon AP,Sharpe PA,Shivdasani RA Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development (Cambridge, England). 2007();134(20):3603-13 PUBMED | ||||||
| Hartman HA,Lai HL,Patterson LT Cessation of renal morphogenesis in mice. Developmental biology. 2007();310(2):379-87 PUBMED | ||||||
| Ahituv N,Zhu Y,Visel A,Holt A,Afzal V,Pennacchio LA,Rubin EM Deletion of ultraconserved elements yields viable mice. PLoS biology. 2007();5(9):e234 PUBMED | ||||||
| Muthig V,Gilsbach R,Haubold M,Philipp M,Ivacevic T,Gessler M,Hein L Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice. Circulation research. 2007();101(7):682-91 PUBMED | ||||||
| Boyle S,Shioda T,Perantoni AO,de Caestecker M Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 2007();236(8):2321-30 PUBMED | ||||||
| Manuylov NL,Fujiwara Y,Adameyko II,Poulat F,Tevosian SG The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models. Developmental biology. 2007();307(2):356-67 PUBMED | ||||||
| Val P,Martinez-Barbera JP,Swain A Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development (Cambridge, England). 2007();134(12):2349-58 PUBMED | ||||||
| Linton JM,Martin GR,Reichardt LF The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression. Development (Cambridge, England). 2007();134(13):2501-9 PUBMED | ||||||
| Hosen N,Shirakata T,Nishida S,Yanagihara M,Tsuboi A,Kawakami M,Oji Y,Oka Y,Okabe M,Tan B,Sugiyama H,Weissman IL The Wilms' tumor gene WT1-GFP knock-in mouse reveals the dynamic regulation of WT1 expression in normal and leukemic hematopoiesis. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2007();21(8):1783-91 PUBMED | ||||||
| Wilkinson L,Gilbert T,Kinna G,Ruta LA,Pennisi D,Kett M,Little MH Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development. Journal of the American Society of Nephrology : JASN. 2007();18(6):1697-708 PUBMED | ||||||
| Schwab KR,Patterson LT,Hartman HA,Song N,Lang RA,Lin X,Potter SS Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC biology. 2007();5():15 PUBMED | ||||||
| Klattig J,Sierig R,Kruspe D,Besenbeck B,Englert C Wilms' tumor protein Wt1 is an activator of the anti-Müllerian hormone receptor gene Amhr2. Molecular and cellular biology. 2007();27(12):4355-64 PUBMED | ||||||
| Narlis M,Grote D,Gaitan Y,Boualia SK,Bouchard M Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. Journal of the American Society of Nephrology : JASN. 2007();18(4):1121-9 PUBMED | ||||||
| Schulte I,Schlueter J,Abu-Issa R,Brand T,Männer J Morphological and molecular left-right asymmetries in the development of the proepicardium: a comparative analysis on mouse and chick embryos. Developmental dynamics : an official publication of the American Association of Anatomists. 2007();236(3):684-95 PUBMED | ||||||
| Cheng HT,Kim M,Valerius MT,Surendran K,Schuster-Gossler K,Gossler A,McMahon AP,Kopan R Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (Cambridge, England). 2007();134(4):801-11 PUBMED | ||||||
| Mahoney ZX,Sammut B,Xavier RJ,Cunningham J,Go G,Brim KL,Stappenbeck TS,Miner JH,Swat W Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. Proceedings of the National Academy of Sciences of the United States of America. 2006();103(52):19872-7 PUBMED | ||||||
| Di Renzo F,Doneda L,Menegola E,Sardella M,De Vecchi G,Collini P,Spreafico F,Fossati-Bellani F,Giavini E,Radice P,Perotti D The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors. Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology. 2006();28(12):791-7 PUBMED | ||||||
| Clugston RD,Klattig J,Englert C,Clagett-Dame M,Martinovic J,Benachi A,Greer JJ Teratogen-induced, dietary and genetic models of congenital diaphragmatic hernia share a common mechanism of pathogenesis. The American journal of pathology. 2006();169(5):1541-9 PUBMED | ||||||
| Liu G,Clement LC,Kanwar YS,Avila-Casado C,Chugh SS ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. The Journal of biological chemistry. 2006();281(51):39681-92 PUBMED | ||||||
| Self M,Lagutin OV,Bowling B,Hendrix J,Cai Y,Dressler GR,Oliver G Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. The EMBO journal. 2006();25(21):5214-28 PUBMED | ||||||
| Ikeya M,Kawada M,Kiyonari H,Sasai N,Nakao K,Furuta Y,Sasai Y Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development (Cambridge, England). 2006();133(22):4463-73 PUBMED | ||||||
| Lahiri D,Dutton JR,Duarte A,Moorwood K,Graham CF,Ward A Nephropathy and defective spermatogenesis in mice transgenic for a single isoform of the Wilms' tumour suppressor protein, WT1-KTS, together with one disrupted Wt1 allele. Molecular reproduction and development. 2007();74(3):300-11 PUBMED | ||||||
| Schmidt-Ott KM,Chen X,Paragas N,Levinson RS,Mendelsohn CL,Barasch J c-kit delineates a distinct domain of progenitors in the developing kidney. Developmental biology. 2006();299(1):238-49 PUBMED | ||||||
| Kirschner KM,Wagner N,Wagner KD,Wellmann S,Scholz H The Wilms tumor suppressor Wt1 promotes cell adhesion through transcriptional activation of the alpha4integrin gene. The Journal of biological chemistry. 2006();281(42):31930-9 PUBMED | ||||||
| Gao F,Maiti S,Alam N,Zhang Z,Deng JM,Behringer RR,Lécureuil C,Guillou F,Huff V The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis. Proceedings of the National Academy of Sciences of the United States of America. 2006();103(32):11987-92 PUBMED | ||||||
| Guo JK,Ardito TA,Kashgarian M,Krause DS Prevention of mesangial sclerosis by bone marrow transplantation. Kidney international. 2006();70(5):910-3 PUBMED | ||||||
| Griffin SV,Olivier JP,Pippin JW,Roberts JM,Shankland SJ Cyclin I protects podocytes from apoptosis. The Journal of biological chemistry. 2006();281(38):28048-57 PUBMED | ||||||
| Seo S,Kume T Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Developmental biology. 2006();296(2):421-36 PUBMED | ||||||
| Reinholdt LG,Munroe RJ,Kamdar S,Schimenti JC The mouse gcd2 mutation causes primordial germ cell depletion. Mechanisms of development. 2006();123(7):559-69 PUBMED | ||||||
| James RG,Kamei CN,Wang Q,Jiang R,Schultheiss TM Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. Development (Cambridge, England). 2006();133(15):2995-3004 PUBMED | ||||||
| Wagner N,Wagner KD,Scholz H,Kirschner KM,Schedl A Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1. American journal of physiology. Regulatory, integrative and comparative physiology. 2006();291(3):R779-87 PUBMED | ||||||
| Airik R,Bussen M,Singh MK,Petry M,Kispert A Tbx18 regulates the development of the ureteral mesenchyme. The Journal of clinical investigation. 2006();116(3):663-74 PUBMED | ||||||
| Hirose T,Karasawa M,Sugitani Y,Fujisawa M,Akimoto K,Ohno S,Noda T PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development (Cambridge, England). 2006();133(7):1389-98 PUBMED | ||||||
| Takemoto M,He L,Norlin J,Patrakka J,Xiao Z,Petrova T,Bondjers C,Asp J,Wallgard E,Sun Y,Samuelsson T,Mostad P,Lundin S,Miura N,Sado Y,Alitalo K,Quaggin SE,Tryggvason K,Betsholtz C Large-scale identification of genes implicated in kidney glomerulus development and function. The EMBO journal. 2006();25(5):1160-74 PUBMED | ||||||
| Veith AM,Klattig J,Dettai A,Schmidt C,Englert C,Volff JN Male-biased expression of X-chromosomal DM domain-less Dmrt8 genes in the mouse. Genomics. 2006();88(2):185-95 PUBMED | ||||||
| Dame C,Kirschner KM,Bartz KV,Wallach T,Hussels CS,Scholz H Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene. Blood. 2006();107(11):4282-90 PUBMED | ||||||
| Niakan KK,Davis EC,Clipsham RC,Jiang M,Dehart DB,Sulik KK,McCabe ER Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis. Molecular genetics and metabolism. 2006();88(3):261-71 PUBMED | ||||||
| Poladia DP,Kish K,Kutay B,Hains D,Kegg H,Zhao H,Bates CM Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme. Developmental biology. 2006();291(2):325-39 PUBMED | ||||||
| Rao MK,Pham J,Imam JS,MacLean JA,Murali D,Furuta Y,Sinha-Hikim AP,Wilkinson MF Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. Genes & development. 2006();20(2):147-52 PUBMED | ||||||
| Osafune K,Takasato M,Kispert A,Asashima M,Nishinakamura R Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. Development (Cambridge, England). 2006();133(1):151-61 PUBMED | ||||||
| Grote D,Souabni A,Busslinger M,Bouchard M Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development (Cambridge, England). 2006();133(1):53-61 PUBMED | ||||||
| Gao X,Chen X,Taglienti M,Rumballe B,Little MH,Kreidberg JA Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa. Development (Cambridge, England). 2005();132(24):5437-49 PUBMED | ||||||
| Desmots F,Russell HR,Lee Y,Boyd K,McKinnon PJ The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development. Molecular and cellular biology. 2005();25(23):10329-37 PUBMED | ||||||
| Wilm B,Ipenberg A,Hastie ND,Burch JB,Bader DM The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature. Development (Cambridge, England). 2005();132(23):5317-28 PUBMED | ||||||
| Wagner N,Wagner KD,Theres H,Englert C,Schedl A,Scholz H Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. Genes & development. 2005();19(21):2631-42 PUBMED | ||||||
| Patek CE,Saunders PT,Miles CG,Berry RL,Hastie ND,Sharpe RM,Hooper ML Gonadal effects of a mouse Denys-Drash syndrome mutation. Transgenic research. 2005();14(5):691-702 PUBMED | ||||||
| Wang Q,Lan Y,Cho ES,Maltby KM,Jiang R Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development. Developmental biology. 2005();288(2):582-94 PUBMED | ||||||
| Carroll TJ,Park JS,Hayashi S,Majumdar A,McMahon AP Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Developmental cell. 2005();9(2):283-92 PUBMED | ||||||
| Grieshammer U,Cebrián C,Ilagan R,Meyers E,Herzlinger D,Martin GR FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development (Cambridge, England). 2005();132(17):3847-57 PUBMED | ||||||
| Naz RK,Rajesh C Gene knockouts that cause female infertility: search for novel contraceptive targets. Frontiers in bioscience : a journal and virtual library. 2005();10():2447-59 PUBMED | ||||||
| Brendolan A,Ferretti E,Salsi V,Moses K,Quaggin S,Blasi F,Cleary ML,Selleri L A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Development (Cambridge, England). 2005();132(13):3113-26 PUBMED | ||||||
| Bouma GJ,Albrecht KH,Washburn LL,Recknagel AK,Churchill GA,Eicher EM Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Development (Cambridge, England). 2005();132(13):3045-54 PUBMED | ||||||
| Töhönen V,Frygelius J,Mohammadieh M,Kvist U,Pelliniemi LJ,O'Brien K,Nordqvist K,Wedell A Normal sexual development and fertility in testatin knockout mice. Molecular and cellular biology. 2005();25(12):4892-902 PUBMED | ||||||
| Tse HK,Leung MB,Woolf AS,Menke AL,Hastie ND,Gosling JA,Pang CP,Shum AS Implication of Wt1 in the pathogenesis of nephrogenic failure in a mouse model of retinoic acid-induced caudal regression syndrome. The American journal of pathology. 2005();166(5):1295-307 PUBMED | ||||||
| Matsuyama M,Mizusaki H,Shimono A,Mukai T,Okumura K,Abe K,Shimada K,Morohashi K A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes to cells : devoted to molecular & cellular mechanisms. 2005();10(5):421-34 PUBMED | ||||||
| Wagner N,Wagner KD,Hammes A,Kirschner KM,Vidal VP,Schedl A,Scholz H A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system. Development (Cambridge, England). 2005();132(6):1327-36 PUBMED | ||||||
| Gray PA,Fu H,Luo P,Zhao Q,Yu J,Ferrari A,Tenzen T,Yuk DI,Tsung EF,Cai Z,Alberta JA,Cheng LP,Liu Y,Stenman JM,Valerius MT,Billings N,Kim HA,Greenberg ME,McMahon AP,Rowitch DH,Stiles CD,Ma Q Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (New York, N.Y.). 2004();306(5705):2255-7 PUBMED | ||||||
| Bouma GJ,Hart GT,Washburn LL,Recknagel AK,Eicher EM Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development. Gene expression patterns : GEP. 2004();5(1):141-9 PUBMED | ||||||
| Gao F,Maiti S,Sun G,Ordonez NG,Udtha M,Deng JM,Behringer RR,Huff V The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome. Molecular and cellular biology. 2004();24(22):9899-910 PUBMED | ||||||
| Hahn H,Nitzki F,Schorban T,Hemmerlein B,Threadgill D,Rosemann M Genetic mapping of a Ptch1-associated rhabdomyosarcoma susceptibility locus on mouse chromosome 2. Genomics. 2004();84(5):853-8 PUBMED | ||||||
| Cebrián C,Borodo K,Charles N,Herzlinger DA Morphometric index of the developing murine kidney. Developmental dynamics : an official publication of the American Association of Anatomists. 2004();231(3):601-8 PUBMED | ||||||
| Oxburgh L,Chu GC,Michael SK,Robertson EJ TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development (Cambridge, England). 2004();131(18):4593-605 PUBMED | ||||||
| Mok H,Mendoza M,Prchal JT,Balogh P,Schumacher A Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice. Development (Cambridge, England). 2004();131(19):4871-81 PUBMED | ||||||
| Hecksher-Sørensen J,Watson RP,Lettice LA,Serup P,Eley L,De Angelis C,Ahlgren U,Hill RE The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2. Development (Cambridge, England). 2004();131(19):4665-75 PUBMED | ||||||
| Brennan J,Capel B One tissue, two fates: molecular genetic events that underlie testis versus ovary development. Nature reviews. Genetics. 2004();5(7):509-21 PUBMED | ||||||
| Wilm B,James RG,Schultheiss TM,Hogan BL The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. Developmental biology. 2004();271(1):176-89 PUBMED | ||||||
| Natoli TA,Alberta JA,Bortvin A,Taglienti ME,Menke DB,Loring J,Jaenisch R,Page DC,Housman DE,Kreidberg JA Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. Developmental biology. 2004();268(2):429-40 PUBMED | ||||||
| Mitsunaga K,Araki K,Mizusaki H,Morohashi K,Haruna K,Nakagata N,Giguère V,Yamamura K,Abe K Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos. Mechanisms of development. 2004();121(3):237-46 PUBMED | ||||||
| Discenza MT,Pelletier J Insights into the physiological role of WT1 from studies of genetically modified mice. Physiological genomics. 2004();16(3):287-300 PUBMED | ||||||
| Srichai MB,Konieczkowski M,Padiyar A,Konieczkowski DJ,Mukherjee A,Hayden PS,Kamat S,El-Meanawy MA,Khan S,Mundel P,Lee SB,Bruggeman LA,Schelling JR,Sedor JR A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. The Journal of biological chemistry. 2004();279(14):14398-408 PUBMED | ||||||
| Yoshitomi H,Zaret KS Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development (Cambridge, England). 2004();131(4):807-17 PUBMED | ||||||
| Takamiya K,Kostourou V,Adams S,Jadeja S,Chalepakis G,Scambler PJ,Huganir RL,Adams RH A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1. Nature genetics. 2004();36(2):172-7 PUBMED | ||||||
| Visel A,Thaller C,Eichele G GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic acids research. 2004();32(Database issue):D552-6 PUBMED | ||||||
| Niksic M,Slight J,Sanford JR,Caceres JF,Hastie ND The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes. Human molecular genetics. 2004();13(4):463-71 PUBMED | ||||||
| Clipsham R,Niakan K,McCabe ER Nr0b1 and its network partners are expressed early in murine embryos prior to steroidogenic axis organogenesis. Gene expression patterns : GEP. 2004();4(1):3-14 PUBMED | ||||||
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| Allele Symbol | Allele Name | MGI ID | ENSEMBL | REFSEQ | |
|---|---|---|---|---|---|
| Wt1<tm1Jae> | targeted mutation 1, Rudolf Jaenisch | MGI:1857268 | ENSEMBL | NM_144783 | |
| Wt1<tm1Jak> | targeted mutation 1, Jordan A Kreidberg | MGI:2180792 | ENSEMBL | NM_144783 | |
| Wt1<tm1.1Jak> | targeted mutation 1.1 Jordan A Kreidberg | MGI:2183548 | ENSEMBL | NM_144783 | |
| Wt1<tm1Asc> | targeted mutation 1, Andreas Schedl | MGI:2183640 | ENSEMBL | NM_144783 | |
| Wt1<tm2Asc> | targeted mutation 2, Andreas Schedl | MGI:2183642 | ENSEMBL | NM_144783 | |
| Wt1<tm1Hst> | targeted mutation 1, Nicholas D Hastie | MGI:2654351 | ENSEMBL | NM_144783 | |
| Wt1<tm1Vih> | targeted mutation 1, Vicki Huff | MGI:3512766 | ENSEMBL | NM_144783 | |
| Wt1<tm2Hst> | targeted mutation 2, Nicholas D Hastie | MGI:3610301 | ENSEMBL | NM_144783 | |
| Wt1<tm2Vih> | targeted mutation 2, Vicki Huff | MGI:3665320 | ENSEMBL | NM_144783 | |
| Wt1<tm2.1Vih> | targeted mutation 2.1, Vicki Huff | MGI:3665321 | ENSEMBL | NM_144783 | |
| Wt1<tm1Nhsn> | targeted mutation 1, Naoki Hosen | MGI:3721102 | ENSEMBL | NM_144783 | |
| Wt1<tm1Mlh> | targeted mutation 1, Martin L Hooper | MGI:3794650 | ENSEMBL | NM_144783 | |
| Wt1<tm1(GFP/cre)Wtp> | targeted mutation 1, William T Pu | MGI:3801681 | ENSEMBL | NM_144783 | |
| Wt1<tm2(cre/ESR1)Wtp> | targeted mutation 2, William T Pu | MGI:3801682 | ENSEMBL | NM_144783 | |
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