Stock Tg(TH1-TauV337m)T39

Stock Name

Tg(TH1-TauV337m)T39

FESA Number

1777

Strain Name

Tg(TH1-TauV337m)T39

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Transgenic IMSR - unclassified

Attribution

Mother Genotype

CBA C57BL/6

Father Genotype

Tg(Thy1-TauV337M)T39 +/-

Colony Stock Code

Tg(TH1-TauV337m)T39

Phenotypic Description

Development of abnormal tau phosphorylation & aggregation within the brain, as seen in Alzheimer's & other tauopathies. Highly discrete & specific age-dependent cognitive changes including memory impairment & impaired impulse control.

Publications

Contact/Order

For more information or to order stocks, Contact us

Breeding Notes

TauV337M transgenic mice were produced by pronuclear injection of (C57BL/6J x CBA/Ca) F1 embryos. Founder animals inter-crossed with C57BL/6J x CBA/Ca F1 mice to establish experimental lines.

Homozygous Mice Viable

Homozygous Mice Fertile

Immuno-Compromised