Stock Tg(ACTA2-TFPI/CD4/SELP)#aAdor

FESA Number

6974

Strain Name

Tg(ACTA2-TFPI/CD4/SELP)#aAdor

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Transgenic IMSR - unclassified

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained
Unknown Institution Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Tg(ACTA2-TFPI/CD4/SELP)#aAdor MGI:5578126 Tg(ACTA2-TFPI/CD4/SELP)#aAdor MGI:5578154

Phenotypic Description

Mice express membrane tethered human TFPI-CD4 fusion protein on all alpha-SMA+ (alpha smooth muscle actin) cells. In cells with secretory granules, these will be internalised at resting state by virtue of P-selectin cytoplasmic sequence. The hTFPI (human tissue factor pathway inhibitor)inhibits tissue factor and FXa (factor Xa).

Publications

EMMA ID

EM:08451

Genetic Status

GMO

Background Strain Name

C57BL/6

Background Strain MGI ID

MGI:2159769

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