Stock T(2;11)30H - cross 4

Stock Name

T(2;11)30H - cross 4

FESA Number

3501

Strain Name

T(2;11)30H - cross 4

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - reciprocal translocation IMSR - unclassified

Attribution

Mother Genotype

pa a bp/+ a bp or + a bp/+ a bp

Father Genotype

+ a<T30H> +/+ a bp (or vice versa) [Proven]

Colony Stock Code

T30H

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome Is Background
T(2;11)30H MGI:103721 11

Phenotypic Description

Reciprocal translocation between Chr2 and Chr11 with breakpoints at 2H1 and 11B1. The breakpoint on Chr2 disrupts the agouti locus such that T30H/a animals look non-agouti. T30H/T30H were originally considered to be lethal prenatally. However, it was subsequently discovered that homozygote numbers at birth from intercrosses are probably at expected frequencies. Viability is affected by genetic background: early death is more prevalent on a C3H/HeH-101/H background than on a JU.CBA-c<+> background. Homozygotes exhibit extensive hydronephrosis and have a highly distended bladder. Handling of the pups can stimulate urination. Frequent induction of urination can extend survival to early adulthood (most homozygotes would otherwise die before two weeks of age). See Cattanach BM & Kirk M (1987) Mouse News Letter 78,52.

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Homozygous Mice Viable

Homozygous Mice Fertile

Immuno-Compromised