Stock STOCK Nox3<het>/JH

Stock Name

het (head-tilt)

FESA Number

1591

Strain Name

STOCK Nox3<het>/JH

MGI ID

MGI:1856606

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Spontaneous mutation IMSR - unclassified

Attribution

Mother Genotype

C57BL/6J

Father Genotype

het/het, a/a

Colony Stock Code

het (head-tilt)

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome Is Background
Nox3<het> MGI:1856606 Nox3 MGI:2681162 17

Phenotypic Description

Heterozygotes can have abnormal circling behaviour & hyperactivity. Homozygotes also exhibit a subtle head tilt.

Publications

Displaying 1 - 10 of 11 Stock Publications
Pubmed ID Authors Title Journal
9755211 Bergstrom RA Deletion mapping of the head tilt (het) gene in mice: a vestibular mutation causing specific absence of otoliths. Genetics (1 998) 150:815-22
21161235 Flaherty JP Molecular characterization of an allelic series of mutations in the mouse Nox3 gene. Mamm Genome (2 011) 22:156-69
12434016 Fuller PM Neurovestibular modulation of circadian and homeostatic regulation: vestibulohypothalamic connection? Proc Natl Acad Sci U S A (2 002) 99:15723-8
12711080 Harrod CG The vestibulo ocular reflex (VOR) in otoconia deficient head tilt (het) mutant mice versus wild type C57BL/6 mice. Brain Res (2 003) 972:75-83
17023128 Hoffman LF Afferent synapses are present in utricular hair cells from otoconia-deficient mice. Hear Res (2 006) 222:35-42
10491954 Jones SM Vestibular responses to linear acceleration are absent in otoconia-deficient C57BL/6JEi-het mice. Hear Res (1 999) 135:56-60
10835400 Lyon MF Narrowing the critical regions for mouse t complex transmission ratio distortion factors by use of deletions. Genetics (2 000) 155:793-801
15014044 Paffenholz R Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase. Genes Dev (2 004) 18:486-91
Sweet HO Head tilt (het) Mouse News Lett (1 980) 63:19
15059776 Xue B Diminished baroreflex control of heart rate responses in otoconia-deficient C57BL/6JEi head tilt mice. Am J Physiol Heart Circ Physiol (2 004) 287:H741-7

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Homozygous Mice Viable

Homozygous Mice Fertile

Immuno-Compromised