Stock STOCK Egr2<tm3Pch> Tg(CD2-cre)4Kio/H
FESA Number
3549
Strain Name
STOCK Egr2<tm3Pch> Tg(CD2-cre)4Kio/H
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Targeted mutation - Knock out | IMSR - mutant strain |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| Unknown Institution | Originator | Retained |
| Unknown Institution | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Egr2<tm3Pch> | MGI:2183227 | Egr2 | MGI:95296 | 10 |
| Tg(CD2-icre)4Kio | MGI:2449947 | Tg(CD2-icre)4Kio | MGI:2449946 |
Phenotypic Description
Spontaneous autoimmune diseases start at late age (12 months).
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 64 748 | Dejerine-Sottas syndrome | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=64748 |
| 101 084 | Charcot-Marie-Tooth disease type 1D | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=101084 |
| 99 951 | Charcot-Marie-Tooth disease type 4E | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=99951 |
Publications
Displaying 1 - 10 of 47 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 21267074 | Cifuentes-Diaz C | Nodes of ranvier and paranodes in chronic acquired neuropathies. | PLoS One (2 011) 6:e14533 |
| 23548837 | Zheng Y | Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy. | Mol Immunol (2 013) 55:283-91 |
| 23203924 | Miao T | Early growth response gene-2 controls IL-17 expression and Th17 differentiation by negatively regulating Batf. | J Immunol (2 013) 190:58-65 |
| 20427655 | Coulpier F | CNS/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20/Egr2 function. | J Neurosci (2 010) 30:5958-67 |
| 18779345 | Zhu B | Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease. | J Exp Med (2 008) 205:2295-307 |
| 21098124 | Mylona A | The essential function for serum response factor in T-cell development reflects its specific coupling to extracellular signal-regulated kinase signaling. | Mol Cell Biol (2 011) 31:267-76 |
| 16988048 | Decker L | Peripheral myelin maintenance is a dynamic process requiring constant Krox20 expression. | J Neurosci (2 006) 26:9771-9 |
| 23300832 | Almeida AR | RET/GFR? signals are dispensable for thymic T cell development in vivo. | PLoS One (2 012) 7:e52949 |
| 24404186 | Norrie IC | C/EBP? is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner. | PLoS One (2 014) 9:e84728 |
| 23355739 | Dutta M | A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes. | J Immunol (2 013) 190:2121-8 |
Pages
Orphanet Categories
Rare neurologic disease
EMMA ID
EM:04482
Production Information
| Cre-Lox Recombination based excision |
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