Stock STOCK Egr2<tm3Pch> Tg(CD2-cre)4Kio/H

FESA Number

3549

Strain Name

STOCK Egr2<tm3Pch> Tg(CD2-cre)4Kio/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation - Knock out IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained
Unknown Institution Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Egr2<tm3Pch> MGI:2183227 Egr2 MGI:95296 10
Tg(CD2-icre)4Kio MGI:2449947 Tg(CD2-icre)4Kio MGI:2449946

Phenotypic Description

Spontaneous autoimmune diseases start at late age (12 months).

Orphanet Disorders

OrphaNet ID Name Url
64 748 Dejerine-Sottas syndrome http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=64748
101 084 Charcot-Marie-Tooth disease type 1D http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=101084
99 951 Charcot-Marie-Tooth disease type 4E http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=99951

Publications

Displaying 1 - 10 of 47 Stock Publications
Pubmed ID Authors Title Journal
21267074 Cifuentes-Diaz C Nodes of ranvier and paranodes in chronic acquired neuropathies. PLoS One (2 011) 6:e14533
23548837 Zheng Y Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy. Mol Immunol (2 013) 55:283-91
23203924 Miao T Early growth response gene-2 controls IL-17 expression and Th17 differentiation by negatively regulating Batf. J Immunol (2 013) 190:58-65
20427655 Coulpier F CNS/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20/Egr2 function. J Neurosci (2 010) 30:5958-67
18779345 Zhu B Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease. J Exp Med (2 008) 205:2295-307
21098124 Mylona A The essential function for serum response factor in T-cell development reflects its specific coupling to extracellular signal-regulated kinase signaling. Mol Cell Biol (2 011) 31:267-76
16988048 Decker L Peripheral myelin maintenance is a dynamic process requiring constant Krox20 expression. J Neurosci (2 006) 26:9771-9
23300832 Almeida AR RET/GFR? signals are dispensable for thymic T cell development in vivo. PLoS One (2 012) 7:e52949
24404186 Norrie IC C/EBP? is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner. PLoS One (2 014) 9:e84728
23355739 Dutta M A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes. J Immunol (2 013) 190:2121-8

Pages

Orphanet Categories

Rare neurologic disease

EMMA ID

EM:04482

Production Information

Cre-Lox Recombination based excision

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