Stock

FESA Number

6900

Strain Name

STOCK Cacna2d1<tm1Aschw>/AschwAdlpnH

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant stock

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained
University College London Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Cacna2d1<tm1Aschw> MGI:4353680 Cacna2d1 MGI:88295 5

Phenotypic Description

Mice homozygous for this mutation exhibit a smooth muscle deficiency and increased urination. Homozygous males are impotent. Cacna2d1<tm1Aschw>/Cacna2d1<tm1Aschw> mice lack gabapentin (GPB) binding sites, show decreased basal myocardial contractility and relaxation, and decreased L-type calcium currents in cardiomyocytes. Homozygous males have reduced mechanosensory responses and delayed development of neuropathic mechanical hypersensitivity following sensory nerve injury. Heterozygotes have no overt phenotype.

Publications

Displaying 1 - 2 of 2 Stock Publications
Pubmed ID Authors Title Journal
19429829 Fuller-Bicer GA Targeted disruption of the voltage-dependent calcium channel alpha2/delta-1-subunit. Am J Physiol Heart Circ Physiol (2 009) 297:H117-24
24133248 Patel R ?2?-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage. J Neurosci (2 013) 33:16412-26

EMMA ID

EM:08421

Genetic Status

GMO

Background Strain Name

C57BL/6

Background Strain MGI ID

MGI:2159769

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