Stock

FESA Number

6524

Strain Name

SJL/J Lgals1tm1Rob

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Lgals1<tm1Rob> MGI:2181809 Lgals1 MGI:96777 15

Phenotypic Description

These mice are susceptible to Theiler Murine Encephalomyelitis Virus infection and can be used to model primary progressive multiple sclerosis. During the backcrossing there was high mortality rate amongst litters and very poor breeding due to aversion to other mouse strain pheromones. SJL/J males also exhibited significant aggression often resulting in amyloidosis (sequel of social submissiveness and consequent wounds) in female breeding partners which were often very severe and required culling.

Publications

Displaying 1 - 10 of 48 Stock Publications
Pubmed ID Authors Title Journal
23616571 Anginot A Galectin 1 modulates plasma cell homeostasis and regulates the humoral immune response. J Immunol (2 013) 190:5526-33
17110462 Garín MI Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood (2 007) 109:2058-65
23118208 Orr SL A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins. Glycobiology (2 013) 23:363-80
21546572 Banh A Tumor galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis. Cancer Res (2 011) 71:4423-31
19766118 Gaudet AD A role for galectin-1 in the immune response to peripheral nerve injury. Exp Neurol (2 009) 220:320-7
17486104 Plachta N Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells. Nat Neurosci (2 007) 10:712-9
17182582 Barrionuevo P A novel function for galectin-1 at the crossroad of innate and adaptive immunity: galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway. J Immunol (2 007) 178:436-45
17366633 Georgiadis V Lack of galectin-1 results in defects in myoblast fusion and muscle regeneration. Dev Dyn (2 007) 236:1014-24
8306885 Poirier F Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin. Development (1 993) 119:1229-36
24979200 Bastón JI Targeting galectin-1-induced angiogenesis mitigates the severity of endometriosis. J Pathol (2 014) 234:329-37

Pages

EMMA ID

EM:07421

Contact/Order

For more information or to order stocks, Contact us