Stock SJL.129(B6)-Nr1i2<tm1Sakl>/H

FESA Number

3554

Strain Name

SJL.129(B6)-Nr1i2<tm1Sakl>/H

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Nr1i2<tm1Sakl> MGI:3609633 Nr1i2 MGI:1337040 16

Phenotypic Description

The PXR regulates the inducible expression of the major drug metabolising cytochrome P450 3a subfamily of enzymes, which are also responsible for the metabolism of elevated levels of bile acids. Knock out animals therefore do not respond to inducers such as pregnenolone 16alpha carbonitrile and show sensitivity to elevated bile acid levels (liver damage). The SJL background shows an unusual constititively high level of portal tract inflammation (Jones DE, Palmer JM, Kirby JA, De Cruz DJ, McCaughan GW, Sedgwick JD, Yeaman SJ, Burt AD, Bassendine MF. Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy. Liver. 2000 Oct;20(5):351-6.). This strain (along with its wild type) is therefore a model for examining the effects of drugs and bile acids on portal tract inflammation.

Publications

Displaying 21 - 26 of 26 Stock Publications
Pubmed ID Authors Title Journal
15456926 Guo GL Enhanced acetaminophen toxicity by activation of the pregnane X receptor. Toxicol Sci (2 004) 82:374-80
17159084 Hagedorn KA Regulation of vascular tone during pregnancy: a novel role for the pregnane X receptor. Hypertension (2 007) 49:328-33
17093002 Ma X The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A. Drug Metab Dispos (2 007) 35:194-200
19815629 Milona A The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr. Am J Physiol Gastrointest Liver Physiol (2 010) 298:G151-8
21376070 Mota LC Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment. Toxicol Appl Pharmacol (2 011) 252:259-67
17267396 Nakamura K Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver. J Biol Chem (2 007) 282:9768-76

Pages

EMMA ID

EM:04546

Genetic Status

GMO

Strain Sanitary Status

Conventional

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