Stock SJL.129(B6)-Nr1i2<tm1Sakl>/H

FESA Number

3554

Strain Name

SJL.129(B6)-Nr1i2<tm1Sakl>/H

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Nr1i2<tm1Sakl> MGI:3609633 Nr1i2 MGI:1337040 16

Phenotypic Description

The PXR regulates the inducible expression of the major drug metabolising cytochrome P450 3a subfamily of enzymes, which are also responsible for the metabolism of elevated levels of bile acids. Knock out animals therefore do not respond to inducers such as pregnenolone 16alpha carbonitrile and show sensitivity to elevated bile acid levels (liver damage). The SJL background shows an unusual constititively high level of portal tract inflammation (Jones DE, Palmer JM, Kirby JA, De Cruz DJ, McCaughan GW, Sedgwick JD, Yeaman SJ, Burt AD, Bassendine MF. Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy. Liver. 2000 Oct;20(5):351-6.). This strain (along with its wild type) is therefore a model for examining the effects of drugs and bile acids on portal tract inflammation.

Publications

Displaying 11 - 20 of 26 Stock Publications
Pubmed ID Authors Title Journal
16825189 Ding X Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha. J Biol Chem (2 006) 281:26540-51
11602523 Staudinger J Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. Drug Metab Dispos (2 001) 29:1467-72
22815676 Dou W Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis. PLoS One (2 012) 7:e36075
11248085 Staudinger JL The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A (2 001) 98:3369-74
20173028 Dubrac S Modulation of T lymphocyte function by the pregnane X receptor. J Immunol (2 010) 184:2949-57
20416375 Wallace K The PXR is a drug target for chronic inflammatory liver disease. J Steroid Biochem Mol Biol (2 010) 120:137-48
18778245 Finn RD Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. Biochem J (2 009) 417:43-54
16606610 Yamamoto Y Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. J Biol Chem (2 006) 281:16625-31
12923173 Guo GL Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. J Biol Chem (2 003) 278:45062-71
21826054 Yamazaki Y Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver. Lab Invest (2 011) 91:1624-33

Pages

EMMA ID

EM:04546

Genetic Status

GMO

Strain Sanitary Status

Conventional

Contact/Order

For more information or to order stocks, Contact us