Stock

FESA Number

3554

Strain Name

SJL.129(B6)-Nr1i2<tm1Sakl>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - unclassified

Attribution

Institution name Depositor / Originator Name
University of Newcastle Originator Retained
University of Newcastle Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Nr1i2<tm1Sakl> MGI:3609633 Nr1i2 MGI:1337040 16

Phenotypic Description

The PXR regulates the inducible expression of the major drug metabolising cytochrome P450 3a subfamily of enzymes, which are also responsible for the metabolism of elevated levels of bile acids. Knock out animals therefore do not respond to inducers such as pregnenolone 16alpha carbonitrile and show sensitivity to elevated bile acid levels (liver damage). The SJL background shows an unusual constititively high level of portal tract inflammation (Jones DE, Palmer JM, Kirby JA, De Cruz DJ, McCaughan GW, Sedgwick JD, Yeaman SJ, Burt AD, Bassendine MF. Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy. Liver. 2000 Oct;20(5):351-6.). This strain (along with its wild type) is therefore a model for examining the effects of drugs and bile acids on portal tract inflammation.

Publications

Displaying 1 - 10 of 26 Stock Publications
Pubmed ID Authors Title Journal
17521389 Amador-Noguez D Alterations in xenobiotic metabolism in the long-lived Little mice. Aging Cell (2 007) 6:453-70
22503787 Park YJ Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice. Toxicol Appl Pharmacol (2 012) 263:131-7
18648086 Cheng X Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors. Toxicol Sci (2 008) 106:29-36
23153560 Poulton EJ Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo. Toxicol Appl Pharmacol (2 013) 266:122-31
18703564 Cheng X Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers. Toxicol Sci (2 008) 106:37-45
17170021 Shah YM Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression. Am J Physiol Gastrointest Liver Physiol (2 007) 292:G1114-22
19141872 Cho JY Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation. J Lipid Res (2 009) 50:924-37
23626729 Shizu R Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor ? (PPAR?) is enhanced by pregnane X receptor (PXR) activation in mice. PLoS One (2 013) 8:e61802
19407337 Cui YJ Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice. Toxicol Sci (2 009) 110:47-60
24362030 Spruiell K Role of pregnane X receptor in obesity and glucose homeostasis in male mice. J Biol Chem (2 014) 289:3244-61

Pages

EMMA ID

EM:04546

Genetic Status

GMO

Strain Sanitary Status

Conventional

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