Stock

FESA Number

1885

Strain Name

B6.Cg-Tyr<c-Brd> Mir155<tm1.1Brd>/H

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Mir155<tm1.1Brd> MGI:3709881 Mir155 MGI:2676840 16
Tyr<c-Brd> MGI:3640303 Tyr MGI:98880 7

Phenotypic Description

No visible phenotype is associated with this mutation but the mice do exhibit reduced lung airway remodelling & deficient B-cell, T-cell & dendritic cell function. This mutation is on a C57BL/6<c-/c-> background and is albino in appearance. The BIC mice (EMMA ID EM:02231) have been backcrossed at least 5 times to C57BL/6, thus making them suitable for bone marrow transplantation, without rejection, to any C57BL/6 mice, regardless of coat color.

Orphanet Disorders

OrphaNet ID Name Url
352 734 Minimal pigment oculocutaneous albinism type 1 http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=352734
352 737 Temperature-sensitive oculocutaneous albinism type 1 http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=352737
352 740 Ocular albinism with congenital sensorineural deafness http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=352740
79 434 Oculocutaneous albinism type 1B http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=79434
79 431 Oculocutaneous albinism type 1A http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=79431

Publications

Displaying 11 - 20 of 30 Stock Publications
Pubmed ID Authors Title Journal
23200854 Huffaker TB Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity. Cell Rep (2 012) 2:1697-709
22474390 Martínez-Corral I In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis. Proc Natl Acad Sci U S A (2 012) 109:6223-8
25367574 Hu R miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation. Immunity (2 014) 41:605-19
19661232 Mojumder DK Topical mydriatics affect light-evoked retinal responses in anesthetized mice. Invest Ophthalmol Vis Sci (2 010) 51:567-76
23686497 Hu R MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression. J Immunol (2 013) 190:5972-80
18469339 Molina J Abnormal social behaviors and altered gene expression rates in a mouse model for Potocki-Lupski syndrome. Hum Mol Genet (2 008) 17:2486-95
22113163 Kasinski AL Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer (2 011) 11:849-64
16684884 Paylor R Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc Natl Acad Sci U S A (2 006) 103:7729-34
19234151 Kohlhaas S Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol (2 009) 182:2578-82
17202262 Prosser HM Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei. Proc Natl Acad Sci U S A (2 007) 104:648-53

Pages

Orphanet Categories

Inborn errors of metabolism
Rare skin disease
Rare eye disease

EMMA ID

EM:02231

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