Stock

FESA Number

1885

Strain Name

B6.Cg-Tyr<c-Brd> Mir155<tm1.1Brd>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
Welcome Trust Sanger Institute Originator Retained
Welcome Trust Sanger Institute Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Mir155<tm1.1Brd> MGI:3709881 Mir155 MGI:2676840 16
Tyr<c-Brd> MGI:3640303 Tyr MGI:98880 7

Phenotypic Description

No visible phenotype is associated with this mutation but the mice do exhibit reduced lung airway remodelling & deficient B-cell, T-cell & dendritic cell function. This mutation is on a C57BL/6<c-/c-> background and is albino in appearance. The BIC mice (EMMA ID EM:02231) have been backcrossed at least 5 times to C57BL/6, thus making them suitable for bone marrow transplantation, without rejection, to any C57BL/6 mice, regardless of coat color.

Orphanet Disorders

OrphaNet ID Name Url
352 734 Minimal pigment oculocutaneous albinism type 1 http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=352734
352 737 Temperature-sensitive oculocutaneous albinism type 1 http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=352737
352 740 Ocular albinism with congenital sensorineural deafness http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=352740
79 434 Oculocutaneous albinism type 1B http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=79434
79 431 Oculocutaneous albinism type 1A http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=79431

Publications

Displaying 1 - 10 of 30 Stock Publications
Pubmed ID Authors Title Journal
24270517 Agudo J The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids. Nat Immunol (2 014) 15:54-62
18055230 Vigorito E microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity (2 007) 27:847-59
23264052 Clare S Enhanced susceptibility to Citrobacter rodentium infection in microRNA-155-deficient mice. Infect Immun (2 013) 81:723-32
Bradley A The albino B6 line, C57BL/6-Tyr<c-Brd> MGI Direct Data Submission (2 007) :
25995365 Curtis AM Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1. Proc Natl Acad Sci U S A (2 015) 112:7231-6
21159798 Jukkola PI Secretin deficiency causes impairment in survival of neural progenitor cells in mice. Hum Mol Genet (2 011) 20:1000-7
21385848 Dunand-Sauthier I Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function. Blood (2 011) 117:4490-500
21625383 Lei L Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype. PLoS One (2 011) 6:e20041
23956210 Heymans S Macrophage microRNA-155 promotes cardiac hypertrophy and failure. Circulation (2 013) 128:1420-32
9799267 Liu P Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics (1 998) 150:1155-68

Pages

Orphanet Categories

Inborn errors of metabolism
Rare skin disease
Rare eye disease

EMMA ID

EM:02231

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