Stock

FESA Number

5686

Strain Name

B6.Cg-Tg(Slc16a1-Luc)50Rttr/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Transgenic IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
Imperial College Originator Retained
Imperial College Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Tg(Slc16a1-luc)50Rttr MGI:5465430 Tg(Slc16a1-luc)50Rttr MGI:5465433

Phenotypic Description

When expressed in pancreatic beta cells it renders insulin secretion sensitive to pyruvate and prevents the normal inhibition of insulin secretion induced by exercise, replicating the key features of Exercise-Induced Hyperinsulinism.

Publications

Human Disease Links

OMIM ID: 610021

EMMA ID

EM:06818

Genetic Status

GMO

Background Strain Name

C57BL/6

Background Strain MGI ID

MGI:2159769

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