Stock
FESA Number
5686
Strain Name
B6.Cg-Tg(Slc16a1-Luc)50Rttr/H
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Transgenic | IMSR - mutant strain |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| Imperial College | Originator | Retained |
| Imperial College | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Tg(Slc16a1-luc)50Rttr | MGI:5465430 | Tg(Slc16a1-luc)50Rttr | MGI:5465433 |
Phenotypic Description
When expressed in pancreatic beta cells it renders insulin secretion sensitive to pyruvate and prevents the normal inhibition of insulin secretion induced by exercise, replicating the key features of Exercise-Induced Hyperinsulinism.
Publications
Human Disease Links
OMIM ID: 610021
EMMA ID
EM:06818
Genetic Status
GMO
Background Strain Name
C57BL/6
Background Strain MGI ID
MGI:2159769
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