Stock
FESA Number
5618
Strain Name
B6.Cg-Ddx5<tm1.1Arte> Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/H
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Targeted mutation - Conditional | IMSR - congenic strain |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| Unknown Institution | Originator | Retained |
| Unknown Institution | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Gt(ROSA)26Sor<tm9(cre/ESR1)Arte> | MGI:3763211 | Gt(ROSA)26Sor | MGI:104735 | 6 |
| Ddx5<tm1.1Arte> | MGI:5463981 | Ddx5 | MGI:105037 | 11 |
Phenotypic Description
Mouse strain has no detectable phenotype in the absence of activated Cre.
Tamoxifen treatment induces p68 knockout in multiple tissues; this results in hypoplastic bone marrow and alterations in tissue organisation in the large intestine of a high proportion of mice. However, we have only been able to perform short term experiments. These mice would be ideal for the generation of tissue-specific p68 knockout models.
Publications
Displaying 1 - 10 of 75 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 18690222 | Ananieva O | The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. | Nat Immunol (2 008) 9:1028-36 |
| 22269950 | Hisada K | RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells. | Mol Cell Biol (2 012) 32:1139-49 |
| 24498102 | Nagamachi A | Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function. | PLoS One (2 014) 9:e87425 |
| 24576537 | Saba R | CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways. | Dev Biol (2 014) 389:173-81 |
| 20005806 | Uhlenhaut NH | Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. | Cell (2 009) 139:1130-42 |
| 20808952 | Andreu-Vieyra CV | MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing. | PLoS Biol (2 010) 8: |
| 24446488 | Hu J | Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid. | J Exp Med (2 014) 211:281-95 |
| 20562878 | Natoli TA | Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models. | Nat Med (2 010) 16:788-92 |
| 19729436 | Sabbagh Y | Intestinal npt2b plays a major role in phosphate absorption and homeostasis. | J Am Soc Nephrol (2 009) 20:2348-58 |
| 22896614 | Vaillancourt FH | Evaluation of phosphatidylinositol-4-kinase III? as a hepatitis C virus drug target. | J Virol (2 012) 86:11595-607 |
Pages
EMMA ID
EM:06817
Genetic Status
GMO
Production Information
| Cre-Lox Recombination based excision |
Background Strain Name
C57BL/6J
Background Strain MGI ID
MGI:3028467
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