Stock B6(Cg)-Clec9a<tm1.1Crs>/H

FESA Number

4676

Strain Name

B6(Cg)-Clec9a<tm1.1Crs>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation - Knock out IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained
Unknown Institution Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Clec9a<tm1.1Crs> MGI:5298406 Clec9a MGI:2444608 6

Phenotypic Description

The CD8+ve family of dendritic cells lack expression of DNGR-1 (CLEC9) and are impaired in the cross-priming of T-cells.

Publications

Displaying 1 - 5 of 5 Stock Publications
Pubmed ID Authors Title Journal
22505455 Iborra S The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice. J Clin Invest (2 012) 122:1628-43
Reis e Sousa C Direct Data Submission 2011/12/16 MGI Direct Data Submission (2 011) :
19219027 Sancho D Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature (2 009) 458:899-903
23953115 Schraml BU Genetic tracing via DNGR-1 expression history defines dendritic cells as a hematopoietic lineage. Cell (2 013) 154:843-58
22505458 Zelenay S The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice. J Clin Invest (2 012) 122:1615-27

EMMA ID

EM:05605

Genetic Status

GMO

Background Strain Name

C57BL/6J

Background Strain MGI ID

MGI:3028467

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