Stock B6.C3H;B6-Crh<m1H>
FESA Number
7316
Strain Name
B6.C3H;B6-Crh<m1H>
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Chemically Induced Mutation | IMSR - congenic strain |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| Unknown Institution | Originator | Retained |
| MRC Mammalian Genetics Unit | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Crh<m1H> | MGI:5578654 | Crh | MGI:88496 | 3 |
Phenotypic Description
Heterozygous Crh<m1H> are obese, exhibit muscle wasting, thin skin, hair loss, elevated plasma and urinary corticosterone, hyperglycaemia, hyperinsulinaemia, hypercholesterolemia, hypertryglyceridemia and hyperleptinaemia. They also have low bone mineral density,
hypercalcemia, hypercalciuria and decreased concentrations of plasma PTH and osteocalcin.
Heterozygotes can be visibly distinguished from wild types at about 5-6 weeks of age by their
short, skinny tails and scruffy coat. They also have thin skin and their hair starts to thin as they age.
Publications
Displaying 1 - 1 of 1 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 24302625 | Bentley L | An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess. | Endocrinology (2 014) 155:908-22 |
EMMA ID
EM:09024
Genetic Status
Induced
Background Strain Name
C57BL/6J
Background Strain MGI ID
MGI:3028467
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