Stock B6.C3H;B6-Crh<m1H>

FESA Number

7316

Strain Name

B6.C3H;B6-Crh<m1H>

Mutation Strain Type

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained
MRC Mammalian Genetics Unit Depositor Retained

Phenotypic Description

Heterozygous Crh<m1H> are obese, exhibit muscle wasting, thin skin, hair loss, elevated plasma and urinary corticosterone, hyperglycaemia, hyperinsulinaemia, hypercholesterolemia, hypertryglyceridemia and hyperleptinaemia. They also have low bone mineral density, hypercalcemia, hypercalciuria and decreased concentrations of plasma PTH and osteocalcin. Heterozygotes can be visibly distinguished from wild types at about 5-6 weeks of age by their short, skinny tails and scruffy coat. They also have thin skin and their hair starts to thin as they age.

Publications

EMMA ID

EM:09024

Genetic Status

Induced

Background Strain Name

C57BL/6J

Background Strain MGI ID

MGI:3028467

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