Stock B6.C3-Rab27a<ash> 129-Rab27b<tm1.2Seab>/SeabH

FESA Number

7179

Strain Name

B6.C3-Rab27a<ash> 129-Rab27b<tm1.2Seab>/SeabH

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Rab27a<ash> MGI:1856656 Rab27a MGI:1861441 9
Rab27b<tm1.2Seab> MGI:3706986 Rab27b MGI:1931295 18

Phenotypic Description

The stock has an abnormal coat colour pigmentation (ashen) due to the recessive mutation Rab27a<ash>.

Publications

Displaying 41 - 45 of 45 Stock Publications
Pubmed ID Authors Title Journal
18991284 Pachlopnik Schmid J A Griscelli syndrome type 2 murine model of hemophagocytic lymphohistiocytosis (HLH). Eur J Immunol (2 008) 38:3219-25
23403622 Jessen B The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2. Blood (2 013) 121:2943-51
23160464 Sepulveda FE Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11. Blood (2 013) 121:595-603
21746860 Johnson JL Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation. Infect Immun (2 011) 79:3607-18
Silvers WK The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction (1 979) :

Pages

Human Disease Links

Griscelli Syndrome type 2

EMMA ID

EM:08549

Genetic Status

GMO

Background Strain Name

C57BL/6

Background Strain MGI ID

MGI:2159769

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