Stock B6.C3-Rab27a<ash> 129-Rab27b<tm1.2Seab>/SeabH

FESA Number


Strain Name

B6.C3-Rab27a<ash> 129-Rab27b<tm1.2Seab>/SeabH

Mutation Strain Type


Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Rab27a<ash> MGI:1856656 Rab27a MGI:1861441 9
Rab27b<tm1.2Seab> MGI:3706986 Rab27b MGI:1931295 18

Phenotypic Description

The stock has an abnormal coat colour pigmentation (ashen) due to the recessive mutation Rab27a<ash>.


Displaying 11 - 20 of 45 Stock Publications
Pubmed ID Authors Title Journal
Lane PW Ashen, a new color mutation on chromosome 9 of the mouse. J Hered (1 979) 70:133-135
12907454 Tiwari S A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood (2 003) 102:3970-9
18629000 Chan WT Murine leukemia virus spreading in mice impaired in the biogenesis of secretory lysosomes and Ca2+-regulated exocytosis. PLoS One (2 008) 3:e2713
Lane PW New mutations and enzyme variants Mouse News Lett (1 977) 57:18
14617806 Tolmachova T A general role for Rab27a in secretory cells. Mol Biol Cell (2 004) 15:332-44
22042600 Chen G Lysosomal exocytosis in Schwann cells contributes to axon remyelination. Glia (2 012) 60:295-305
6322428 Langdon WY Relationship between a retroviral germ line reintegration and a new mutation at the ashen locus in B10.F mice. Retroviral integration and an ashen mutation. Virology (1 984) 133:183-90
17384153 Tolmachova T Rab27b regulates number and secretion of platelet dense granules. Proc Natl Acad Sci U S A (2 007) 104:5872-7
21525430 Chiang L Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol (2 011) 301:C507-21
18801842 Merrins MJ Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic beta-cells. J Physiol (2 008) 586:5367-81


Human Disease Links

Griscelli Syndrome type 2



Genetic Status


Background Strain Name


Background Strain MGI ID



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