Stock B6.C3-Rab27a<ash> 129-Rab27b<tm1.2Seab>/SeabH

FESA Number

7179

Strain Name

B6.C3-Rab27a<ash> 129-Rab27b<tm1.2Seab>/SeabH

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - congenic strain

Attribution

Institution name Depositor / Originator Name
Imperial College Originator Retained
Imperial College Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Rab27a<ash> MGI:1856656 Rab27a MGI:1861441 9
Rab27b<tm1.2Seab> MGI:3706986 Rab27b MGI:1931295 18

Phenotypic Description

The stock has an abnormal coat colour pigmentation (ashen) due to the recessive mutation Rab27a<ash>.

Publications

Displaying 1 - 10 of 45 Stock Publications
Pubmed ID Authors Title Journal
20813901 Anderson KE PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils. Blood (2 010) 116:4978-89
15690086 Kasai K Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. J Clin Invest (2 005) 115:388-96
23281710 Singh RK Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion. FEBS J (2 013) 280:892-903
12122117 Barral DC Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest (2 002) 110:247-57
23986549 Kim JD An essential role for Rab27a GTPase in eosinophil exocytosis. J Leukoc Biol (2 013) 94:1265-74
22375060 Singh RK Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment. J Cell Sci (2 012) 125:1652-6
21045126 Blasius AL Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2 010) 107:19973-8
21677130 Koguchi Y Cyclosporine-resistant, Rab27a-independent mobilization of intracellular preformed CD40 ligand mediates antigen-specific T cell help in vitro. J Immunol (2 011) 187:626-34
11266472 Stinchcombe JC Rab27a is required for regulated secretion in cytotoxic T lymphocytes. J Cell Biol (2 001) 152:825-34
21160031 Bolasco G Loss of Rab27 function results in abnormal lung epithelium structure in mice. Am J Physiol Cell Physiol (2 011) 300:C466-76

Pages

Human Disease Links

Griscelli Syndrome type 2

EMMA ID

EM:08549

Genetic Status

GMO

Background Strain Name

C57BL/6

Background Strain MGI ID

MGI:2159769

Contact/Order

For more information or to order stocks, Contact us