Stock B6.C-Ndrg1<str>/H

FESA Number

4505

Strain Name

B6.C-Ndrg1<str>/H

Mutation Strain Type

Attribution

Institution name Depositor / Originator Name
University College London Originator Retained
University College London Depositor Retained

Phenotypic Description

Mice at first develop normally but around the age of 5-6 weeks develop a peripheral demyelinating neuropathy resulting in weakness of the hind limbs. This manifests as clasping hind legs when suspended by tail, marked tremor, inability to maintain normal posture. Signs progress rapidly at first, stabilise after 20 weeks.

Orphanet Disorders

OrphaNet ID Name Url
99 950 Charcot-Marie-Tooth disease type 4D http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=99950

Publications

Human Disease Links

OMIM ID:601455

Orphanet Categories

Rare neurologic disease

EMMA ID

EM:05263

Background Strain Name

C57BL/6J

Background Strain MGI ID

MGI:3028467

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