Stock
FESA Number
4459
Strain Name
B6129S8-Tc(Hsa21)1TybEmcf/H
Mutation Strain Type
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| University College London | Originator | Retained |
| University College London | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Tc(HSA21)1TybEmcf | MGI:3814712 | Tc(HSA21)1TybEmcf | MGI:3814702 |
Phenotypic Description
This strain displays learning abnormalities, reduced long-term potentiation in the hippocampus, heart and brain developmental defects, craniofacial dysmorphology (this strain models human Down syndrome).
Publications
Displaying 1 - 10 of 16 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 23349361 | Ahmed MM | Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain. | Hum Mol Genet (2 013) 22:1709-24 |
| 24068166 | Bhutta MF | Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media. | Mamm Genome (2 013) 24:439-45 |
| 18771760 | Canzonetta C | DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. | Am J Hum Genet (2 008) 83:388-400 |
| 21047530 | Duchon A | The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome. | Behav Brain Res (2 011) 217:271-81 |
| 19181682 | Galante M | Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome. | Hum Mol Genet (2 009) 18:1449-63 |
| 23596509 | Gribble SM | Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome. | PLoS One (2 013) 8:e60482 |
| 22869728 | Grizenkova J | Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice. | Proc Natl Acad Sci U S A (2 012) 109:13722-7 |
| 24205261 | Haas MA | Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome. | PLoS One (2 013) 8:e78561 |
| 18663141 | Mahadevaiah SK | Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation. | J Cell Biol (2 008) 182:263-76 |
| 16179473 | O'Doherty A | An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. | Science (2 005) 309:2033-7 |
Pages
EMMA ID
EM:05291
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