Stock B6129S8-Tc(Hsa21)1TybEmcf/H

FESA Number


Strain Name


Mutation Strain Type


Institution name Depositor / Originator Name
University College London Originator Retained
University College London Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Tc(HSA21)1TybEmcf MGI:3814712 Tc(HSA21)1TybEmcf MGI:3814702

Phenotypic Description

This strain displays learning abnormalities, reduced long-term potentiation in the hippocampus, heart and brain developmental defects, craniofacial dysmorphology (this strain models human Down syndrome).


Displaying 1 - 10 of 16 Stock Publications
Pubmed ID Authors Title Journal
23349361 Ahmed MM Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain. Hum Mol Genet (2 013) 22:1709-24
24068166 Bhutta MF Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media. Mamm Genome (2 013) 24:439-45
18771760 Canzonetta C DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Am J Hum Genet (2 008) 83:388-400
21047530 Duchon A The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome. Behav Brain Res (2 011) 217:271-81
19181682 Galante M Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome. Hum Mol Genet (2 009) 18:1449-63
23596509 Gribble SM Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome. PLoS One (2 013) 8:e60482
22869728 Grizenkova J Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice. Proc Natl Acad Sci U S A (2 012) 109:13722-7
24205261 Haas MA Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome. PLoS One (2 013) 8:e78561
18663141 Mahadevaiah SK Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation. J Cell Biol (2 008) 182:263-76
16179473 O'Doherty A An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science (2 005) 309:2033-7





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