Stock B6.129S-Tecta<tm1Gpr>/H
FESA Number
4844
Strain Name
B6.129S-Tecta<tm1Gpr>/H
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Targeted mutation - Knock out | IMSR - mutant strain |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| Unknown Institution | Originator | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Tecta<tm1Gpr> | MGI:2183148 | Tecta | MGI:109575 | 9 |
Severity Limit
Mild
Phenotypic Description
Homozygous mutant mice suffer hearing loss and have detatched tectorial membranes lacking all non-collagenous matrix.
Publications
Displaying 1 - 5 of 5 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 11087000 | Legan PK | A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback. | Neuron (2 000) 28:273-85 |
| 14523068 | Lukashkin AN | Role of the tectorial membrane revealed by otoacoustic emissions recorded from wild-type and transgenic Tecta(deltaENT/deltaENT) mice. | J Neurophysiol (2 004) 91:163-71 |
| 18516034 | Mellado Lagarde MM | Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier. | Nat Neurosci (2 008) 11:746-8 |
| 21165971 | Verpy E | Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane. | J Comp Neurol (2 011) 519:194-210 |
| 18849963 | Verpy E | Stereocilin-deficient mice reveal the origin of cochlear waveform distortions. | Nature (2 008) 456:255-8 |
Human Disease Links
OMIM IDs 603629
EMMA ID
EM:05538
Genetic Status
GMO
Background Strain Name
C57BL/6J
Background Strain MGI ID
MGI:3028467
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